BRENDA - Enzyme Database
show all sequences of 2.7.1.171

Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin

Delpierrre, G.; Vertommen. D.; Communi, D.; Rider, M.H.; van Schaftingen, E.; J. Biol. Chem. 279, 27613-27620 (2004)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [protein]-N6-D-fructosyl-L-lysine
Homo sapiens
fructosamine-3-kinase phosphorylates fructosamine residues, leading to their destabilization and their shedding from protein
ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [hemoglobin]-N6-D-fructosyl-L-lysine
mass-spectrometric identification of the fructosamine residues that are removed from hemoglobin in intact erythrocytes as a result of the action of fructosamine-3-kinase: Lys16, Lys61 and Lys139 in the alpha-chain of hemoglobin, Val1, Lys17, Lys59, Lys66, Lys132, and Lys144 in the beta-chain of hemoglobin. Some (e.g. Lys139 in the alph-chain of hemoglobin) are readily phosphorylated to a maximal extent by fructosamine-3-kinase in vitro whereas others (e.g. Val1 in the beta-chain of hemoglobin) are slowly and only very partially phosphorylated
708979
Homo sapiens
ADP + [hemoglobin]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
-
-
?
ATP + [protein]-N6-D-fructosyl-L-lysine
fructosamine-3-kinase phosphorylates fructosamine residues, leading to their destabilization and their shedding from protein
708979
Homo sapiens
ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [protein]-N6-D-fructosyl-L-lysine
Homo sapiens
fructosamine-3-kinase phosphorylates fructosamine residues, leading to their destabilization and their shedding from protein
ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [hemoglobin]-N6-D-fructosyl-L-lysine
mass-spectrometric identification of the fructosamine residues that are removed from hemoglobin in intact erythrocytes as a result of the action of fructosamine-3-kinase: Lys16, Lys61 and Lys139 in the alpha-chain of hemoglobin, Val1, Lys17, Lys59, Lys66, Lys132, and Lys144 in the beta-chain of hemoglobin. Some (e.g. Lys139 in the alph-chain of hemoglobin) are readily phosphorylated to a maximal extent by fructosamine-3-kinase in vitro whereas others (e.g. Val1 in the beta-chain of hemoglobin) are slowly and only very partially phosphorylated
708979
Homo sapiens
ADP + [hemoglobin]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
-
-
?
ATP + [protein]-N6-D-fructosyl-L-lysine
fructosamine-3-kinase phosphorylates fructosamine residues, leading to their destabilization and their shedding from protein
708979
Homo sapiens
ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
-
-
?
Other publictions for EC 2.7.1.171
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738074
Cikomola
A simple colorimetric assay fo ...
Homo sapiens
Clin. Chem. Lab. Med.
55
154-159
2017
1
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1
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1
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2
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1
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1
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1
1
-
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-
738073
Avemaria
Possible role of fructosamine ...
Homo sapiens
Clin. Chem. Lab. Med.
53
1315-1320
2015
-
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1
-
1
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1
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1
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1
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2
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1
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4
-
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2
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3
3
-
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-
738072
Hellwig
-
A new HPLC-based assay for the ...
Homo sapiens
Clin. Chem. Lab. Med.
52
93-101
2014
-
-
-
-
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1
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1
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3
-
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-
-
-
-
-
-
2
2
-
-
-
739258
Skrha
Fructosamine 3-kinase and glyo ...
Homo sapiens
Physiol. Res.
63 Suppl 2
S283-S291
2014
-
-
1
-
1
-
-
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-
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2
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2
2
-
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-
707094
van Schaftingen
Enzymatic repair of Amadori pr ...
Homo sapiens, Mus musculus
Amino Acids
42
1143-1150
2012
-
-
-
-
1
-
-
-
-
-
-
2
-
5
-
-
1
-
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1
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2
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1
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1
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1
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2
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-
-
1
1
1
1
-
-
708589
Notarnicola
Reduced fructosamine-3-kinase ...
Homo sapiens
Genes Nutr.
5
257-262
2010
-
-
-
-
-
-
-
-
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2
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2
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-
707061
Pascal
Effects of fructosamine-3-kina ...
Mus musculus
Am. J. Physiol. Endocrinol. Metab.
298
E586-596
2009
-
-
-
-
-
-
-
-
-
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1
-
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3
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1
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1
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1
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1
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1
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-
1
1
-
-
-
708421
Mohas
A polymorphism within the fruc ...
Homo sapiens
Exp. Clin. Endocrinol. Diabetes
118
209-212
2009
-
-
-
-
1
-
-
-
-
-
-
-
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2
-
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710172
Caruso
Gene expression of fructosamin ...
Homo sapiens
Oncology
73
72-75
2008
-
-
-
-
-
-
-
-
-
-
-
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2
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1
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1
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1
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-
707098
Krause
A convenient HPLC assay for th ...
Homo sapiens
Anal. Bioanal. Chem.
386
2019-2025
2006
-
1
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1
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1
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1
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1
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2
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1
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1
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-
707426
Veiga da-Cunha
Increased protein glycation in ...
Mus musculus
Biochem. J.
399
257-264
2006
-
-
-
-
-
-
-
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1
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1
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1
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2
2
-
-
-
708287
Delpierre
Variability in erythrocyte fru ...
Homo sapiens
Diabetes Metab.
32
31-39
2005
-
-
-
-
-
-
-
-
-
-
-
-
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2
-
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2
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2
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707351
Conner
The expression of the genes fo ...
Homo sapiens
Biochem. Biophys. Res. Commun.
323
932-936
2004
-
-
-
-
-
-
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2
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3
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3
-
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1
-
-
1
-
-
708296
Collard
A mammalian protein homologous ...
Homo sapiens, Mus musculus
Diabetes
52
2888-2895
2004
-
-
1
-
-
-
4
4
-
-
-
2
-
4
-
-
1
-
-
8
-
-
7
-
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4
-
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1
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4
4
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4
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2
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1
-
8
-
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7
-
-
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-
708979
Delpierrre
Identification of fructosamine ...
Homo sapiens
J. Biol. Chem.
279
27613-27620
2004
-
-
-
-
-
-
-
-
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-
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1
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2
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1
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2
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1
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1
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2
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708981
Delplanque
Tissue distribution and evolut ...
Gallus gallus, Mus musculus, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
279
46606-46613
2004
-
-
-
-
-
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-
-
-
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3
-
12
-
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3
-
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16
-
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6
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2
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3
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3
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3
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16
-
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6
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2
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3
-
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1
-
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1
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707456
Brown
Modulation of in vivo 3-deoxyg ...
Rattus norvegicus
Biochem. Soc. Trans.
31
1433-1437
2003
-
1
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1
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1
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1
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707420
Delpierre
Fructosamine 3-kinase is invol ...
Homo sapiens
Biochem. J.
365
801-808
2002
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1
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1
1
1
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1
2
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2
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1
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3
1
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1
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1
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1
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708295
Szwergold
Human fructosamine-3-kinase: p ...
Homo sapiens
Diabetes
50
2139-2147
2001
-
-
-
-
-
-
-
4
-
-
1
1
-
2
-
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1
1
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2
1
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6
1
1
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1
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4
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1
1
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1
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2
1
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6
1
1
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1
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708294
Delpierre
Identification, cloning, and h ...
Homo sapiens, Mus musculus
Diabetes
49
1627-1634
2000
-
-
2
-
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-
11
-
-
5
2
-
5
-
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2
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2
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15
2
2
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2
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2
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11
-
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5
2
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2
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2
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15
2
2
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2
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2
2
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