Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CoA | no inhibition in presence of 0.1 mM CoA, activity decrases by 20% in presence of 1 mM CoA | Thermococcus kodakarensis | |
additional information | no detectable decrase in activity at 0.1 mM: acetyl-CoA, dephospho-CoA, or 4'-phosphopantothenate | Thermococcus kodakarensis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.47 | - |
ATP | 42°C | Thermococcus kodakarensis | |
1.2 | - |
Pantoate | 42°C | Thermococcus kodakarensis | |
1.3 | - |
pantothenate | 42°C | Thermococcus kodakarensis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32748 | - |
2 * 32748, calculated from sequence | Thermococcus kodakarensis |
34000 | - |
2 * 34000, SDS-PAGE | Thermococcus kodakarensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pantoate | Thermococcus kodakarensis | - |
ADP + 4-phosphopantoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermococcus kodakarensis | Q5JHF1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pantoate | - |
Thermococcus kodakarensis | ADP + 4-phosphopantoate | - |
? | |
ATP + pantoate | kcat/Km value with pantoate as a substrate is over 7fold higher than that observed with pantothenate | Thermococcus kodakarensis | ADP + 4-phosphopantoate | - |
? | |
ATP + pantothenate | kcat/Km value with pantoate as a substrate is over 7fold higher than that observed with pantothenate | Thermococcus kodakarensis | ADP + 4'-phosphopantothenate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 34000, SDS-PAGE | Thermococcus kodakarensis |
dimer | 2 * 32748, calculated from sequence | Thermococcus kodakarensis |
Synonyms | Comment | Organism |
---|---|---|
PoK | - |
Thermococcus kodakarensis |
TK2141 protein | - |
Thermococcus kodakarensis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
42 | - |
assay | Thermococcus kodakarensis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.21 | - |
pantothenate | 42°C | Thermococcus kodakarensis | |
1.48 | - |
ATP | 42°C | Thermococcus kodakarensis | |
1.56 | - |
Pantoate | 42°C | Thermococcus kodakarensis |
General Information | Comment | Organism |
---|---|---|
malfunction | the deletion mutant strain grows well in media supplemented with 1 mM CoA. The deletion mutant strain could not grow at all in the absence of CoA | Thermococcus kodakarensis |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.17 | - |
pantothenate | 42°C | Thermococcus kodakarensis | |
1.3 | - |
Pantoate | 42°C | Thermococcus kodakarensis | |
3.1 | - |
ATP | 42°C | Thermococcus kodakarensis |