Literature summary for 2.7.1.167 extracted from

Valvano, M.A.; Messner, P.; Kosma, P.
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides (2002), Microbiology, 148, 1979-1989.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
55000	-	x * 55000, SDS-PAGE	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glycero-D-manno-heptose 7-phosphate + ATP	Escherichia coli	-	D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glycero-D-manno-heptose 7-phosphate + ATP	-	Escherichia coli	D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP	-	?
D-glycero-D-manno-heptose 7-phosphate + ATP	bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-D-heptose-1-phosphate adenylyltransferase. Based on genomic sequence comparisons, bifunctional proteins are predicted to be present in several Gram-negative microorganisms, including Agrobacterium tumefaciens, Buchnera sp., Caulobacter crescentus, Salmonella typhimurium, Salmonella typhi, Vibrio cholerae, Yersinia pestis, Haemophilus influenzae, Helicobacter pylori and Pseudomonas aeruginosa. In contrast, individual genes encoding domains I and II independently are found in Ralstonia eutropha, Neisseria meningitidis and Neisseria gonorrhoeae. In these cases, it is proposed to use the nomenclature hldA and hldC to indicate the individual kinase- and adenylyltransferase-encoding genes, respectively	Escherichia coli	D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP	-	?

Subunits

Subunits	Comment	Organism
?	x * 55000, SDS-PAGE	Escherichia coli
More	the N-terminal domain I spans amino acids 1-318 and shares structural features with members of the ribokinase family. The C-terminal domain II, which spans amino acids 344-477, has all the conserved features of the cytidylyltransferase superfamily	Escherichia coli

Synonyms

Synonyms	Comment	Organism
bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase	-	Escherichia coli

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Release 2023.1 (January 2023)