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Literature summary for 2.7.1.158 extracted from
- Urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes (2018), Am. J. Physiol. Renal Physiol., 315, F1484-F1492 .
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | assessing early kidney structural damage in diabetic kidney disease (DKD) via a urine biomarker is an appealing goal, and IPP2K may be a promising candidate | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant expression of His-tagged enzyme in Escherichia coli strain BL21 (Lys) DE3 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| additional information | IPP2K is present in cell nuclei, where it colocalizes with mRNA in the nucleoli, whereas in the cytoplasm it is found principally in stress granules. Distribution of baseline urine inositol 1,3,4,5,6-pentakisphosphate 2-kinase/creatinine (IPP2K/Cr) in women and men, overview | Homo sapiens | - |
- |
| nucleolus | - |
Homo sapiens | 5730 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol hexakisphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9H8X2 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged enzyme from Escherichia coli strain BL21 (Lys) DE3 by nickel affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
| urine | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol hexakisphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | peptide mapping, quantitative LC-selective reaction monitoring-MS (LC-SRM-MS) analysis | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| inositol pentakisphosphate 2-kinase | - |
Homo sapiens |
| IPP2K | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes. A higher prevalence of detectable urinary inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPP2K) in type 1 diabetes correlates with early renal function decline. Proximal tubule cells from people with type 1 diabetes and diabetic kidney disease (DKD) express more IPP2K compared with controls. Demographics and clinical characteristics by tertile of baseline urine inositol 1,3,4,5,6-pentakisphosphate 2-kinase/creatinine (IPP2K/Cr), overview | Homo sapiens |
| physiological function | association of urine inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPP2K) with the presence and progression of diabetic kidney disease (DKD) lesions. Inositol 6-phosphate is a key intracellular signaling molecule with roles in mRNA editing and chromatin remodeling | Homo sapiens |
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