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Literature summary for 2.7.1.158 extracted from

  • Verbsky, J.W.; Wilson, M.P.; Kisseleva, M.V.; Majerus, P.W.; Wente, S.R.
    The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase (2002), J. Biol. Chem., 277, 31857-31862.
    View publication on PubMed
Search for more literature for 2.7.1.158

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf21 cells. Expression of the human enzyme in yeast ipk null strain restores synthesis of 1D-myo-inositol hexakisphosphate and rescues the gle1-2 ipk1-4 lethal phenotype Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 Homo sapiens
0.021
-
 ATP
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
testis
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.031
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol hexakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
-
 Homo sapiens
Ins5 2-kinase
-
 Homo sapiens