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Literature summary for 2.7.1.157 extracted from
- The molecular architecture of human N-acetylgalactosamine kinase (2005), J. Biol. Chem., 280, 32784-32791.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| hanging drop vapor diffusion method, structure auf enzyme solved in presence of Mn-5'-adenylyl-beta,gamma-imidodiphosphate and GalNAc or MgATP and GalNAc (which results in bound products in the active site) | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + N-acetyl-alpha-D-galactosamine | Homo sapiens | the enzyme is involved in a salvage pathway for reutilization of free GalNAc derived from the degradation of complex carbohydrates | ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + N-acetyl-alpha-D-galactosamine | - |
Homo sapiens | ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
? | |
| ATP + N-acetyl-alpha-D-galactosamine | the enzyme is involved in a salvage pathway for reutilization of free GalNAc derived from the degradation of complex carbohydrates | Homo sapiens | ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
? | |
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Release 2023.1 (January 2023)
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