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Literature summary for 2.7.1.154 extracted from

  • Yang, S.; Wu, Q.; Huang, S.; Wang, Z.; Qi, F.
    Sevoflurane and isoflurane inhibit KCl-induced Class II phosphoinositide 3-kinase alpha subunit mediated vasoconstriction in rat aorta (2016), BMC Anesthesiol., 16, 63 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.154

Inhibitors

Inhibitors Comment Organism Structure
Isoflurane ISO, inhibits KCl-stimulated PI3K-C2alpha membrane translocation Rattus norvegicus
LY294002 a PI3K inhibitor, inhibits KCl-elicited rapid and sustained contraction of rat aortic smooth muscle Rattus norvegicus
sevoflurane SEVO, inhibits KCl-stimulated PI3K-C2alpha membrane translocation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information membrane translocation of PI3K-C2alpha in response to KCl Rattus norvegicus
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-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Rattus norvegicus
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 ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus D3ZTF6
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-

Source Tissue

Source Tissue Comment Organism Textmining
aortic smooth muscle
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
class II phosphoinositide 3 kinase alpha subunit
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 Rattus norvegicus
class II phosphoinositide 3-kinase alpha-isoform
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 Rattus norvegicus
PI3K-C2alpha
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction effects of LY294002, sevoflurane (SEVO) and isoflurane (ISO) on KCl-elicited PI3KC2alpha mediated vasoconstriction in rat aortic smooth muscle, overview. PI3K inhibitor LY294002 inhibits PI3K-C2alpha membrane translocation in response to KCl. SEVO and ISO inhibit KCl-stimulated MLC phosphorylation, PI3K-C2alpha and Rock-II, but not PI3K p85, membrane translocation in a concentration-dependent manner in rat aorta Rattus norvegicus
physiological function class II phosphoinositide 3-kinase alpha-isoform (PI3K-C2alpha) is involved in regulating KCl-induced vascular smooth muscle contraction. PI3K-C2alpha mediates part of sevoflurane (SEVO)- and isoflurane (ISO)-mediated vasodilation in rat aorta Rattus norvegicus