Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.154 extracted from

  • Mavrommati, I.; Cisse, O.; Falasca, M.; Maffucci, T.
    Novel roles for class II phosphoinositide 3-kinase C2beta in signalling pathways involved in prostate cancer cell invasion (2016), Sci. Rep., 6, 23277.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens O00750 gene PIK3C2B
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell
-
Homo sapiens
-
prostate cancer cell line
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
class II phosphoinositide 3-kinase C2beta
-
Homo sapiens
PI3K-C2beta
-
Homo sapiens

General Information

General Information Comment Organism
evolution three enzymes belong to the class II subfamily, PI3K-C2alpha, beta, and gamma Homo sapiens
malfunction inhibition of MEK/ERK activation as well as downregulation of PI3K-C2beta does not affect cell proliferation while specifically inhibiting cell invasion Homo sapiens
physiological function isozyme PI3K-C2beta regulates mitogen-activated protein kinase kinase (MEK1/2) and extracellular signal-regulated kinase (ERK1/2) activation in prostate cancer (PCa) cells. MEK/ERK and isozyme PI3K-C2beta are required for PCa cell invasion but not proliferation. MEK/ERK and PI3K-C2beta are not required for PCa cell proliferation. PI3K-C2beta but not MEK/ERK regulates PCa cell migration as well as expression of the transcription factor Slug. PI3K-C2beta regulates FBS-induced PCa cell migration in a mechanism that does not appear to involve MEK/ERK activation Homo sapiens