Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00750 | gene PIK3C2B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate cancer cell | - |
Homo sapiens | - |
prostate cancer cell line | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
class II phosphoinositide 3-kinase C2beta | - |
Homo sapiens |
PI3K-C2beta | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | three enzymes belong to the class II subfamily, PI3K-C2alpha, beta, and gamma | Homo sapiens |
malfunction | inhibition of MEK/ERK activation as well as downregulation of PI3K-C2beta does not affect cell proliferation while specifically inhibiting cell invasion | Homo sapiens |
physiological function | isozyme PI3K-C2beta regulates mitogen-activated protein kinase kinase (MEK1/2) and extracellular signal-regulated kinase (ERK1/2) activation in prostate cancer (PCa) cells. MEK/ERK and isozyme PI3K-C2beta are required for PCa cell invasion but not proliferation. MEK/ERK and PI3K-C2beta are not required for PCa cell proliferation. PI3K-C2beta but not MEK/ERK regulates PCa cell migration as well as expression of the transcription factor Slug. PI3K-C2beta regulates FBS-induced PCa cell migration in a mechanism that does not appear to involve MEK/ERK activation | Homo sapiens |