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Literature summary for 2.7.1.153 extracted from

  • Lacerda-Queiroz, N.; Brant, F.; Rodrigues, D.H.; Vago, J.P.; Rachid, M.A.; Sousa, L.P.; Teixeira, M.M.; Teixeira, A.L.
    Phosphatidylinositol 3-kinase gamma is required for the development of experimental cerebral malaria (2015), PLoS ONE, 10, e0119633.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.153

Protein Variants

Protein Variants Comment Organism
additional information generation of PI3Kgamma-deficient mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
AS605240 a specific PI3Kgamma inhibitor, significantly delays lethality in Plasmodium berghei-infected wild-type micer Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isozyme PI3Kgamma
-
Mus musculus C57BL/6
-
 isozyme PI3Kgamma
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
T-lymphocyte
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
phosphatidylinositol 3-kinase gamma
-
 Mus musculus
PI3Kgamma
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Plasmodium berghei ANKA-infected PI3Kgamm knockout mice show greater survival despite similar parasitemia levels in comparison with infected wild-type mice. Histopathological analysis demonstrates reduced hemorrhage, leukocyte accumulation and vascular obstruction in the brain of infected PI3Kgamma null mice. PI3Kgamma deficiency also causes lower microglial activation and T cell cytotoxicity in the brain. On day 6 post-infection, CD3+/CD8+ T cells are significantly reduced in the brain of infected PI3Kgamma null mice when compared to infected wild-type mice and expression of CD44 in CD8+ T cell population in the brain tissue and levels of phospho-IkappaB-alpha in the whole brain are also markedly lower in infected PI3Kgamma null mice, phenotype, overview Mus musculus
physiological function phosphatidylinositol 3-kinase gamma is central in signaling diverse cellular functions. Relevance of isozyme PI3Kgamma for the outcome and the neuroinflammatory process triggered by Plasmodium berghei ANKA infection Mus musculus