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Literature summary for 2.7.1.153 extracted from

  • Yang, Y.; Iwanaga, K.; Raso, M.G.; Wislez, M.; Hanna, A.E.; Wieder, E.D.; Molldrem, J.J.; Wistuba, I.I.; Powis, G.; Demayo, F.J.; Kim, C.F.; Kurie, J.M.
    Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer (2008), PLoS ONE, 3, e2220.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
PX-866 a PI3K inhibitor, inhibits also the oncogenic K-ras-induced bronchioalveolar stem cell accumulation and tumor growth in vivo Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 two isozymes of the catalytic subunit, p110alpha and p110beta
-

Source Tissue

Source Tissue Comment Organism Textmining
adenocarcinoma cell alveolar Mus musculus
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bronchioalveolar stem cell the cells are located at the terminal bronchi, and have the capacity to selfrenew and undergo multi-linage differentiation Mus musculus
-
lung
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
PI3K
-
 Mus musculus

General Information

General Information Comment Organism
malfunction PI3K is involved in non-small cell lung cancer and is PI3K is required for malignant progression in lung cancer, regulation mechanisms, overview Mus musculus
physiological function phosphatidylinositol 3-kinase is a key mediator of oncogenic K-ras Mus musculus