Literature summary for 2.7.1.153 extracted from

Liu, D.; Zhang, T.; Marshall, A.J.; Okkenhaug, K.; Vanhaesebroeck, B.; Uzonna, J.E.
The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells (2009), J. Immunol., 183, 1921-1933.

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Protein Variants

Protein Variants	Comment	Organism
D910A	mice with an inactivating knock-in mutation in the p110delta isoform of PI3K, p110deltaD910A, generated on Leishmanina major resistant and susceptible genetic backgrounds. The mutant mice show severely impaired T cell responses, but the mutant mice also show more robust resistance to Leishmanina major infection manifested as significantly reduced lesion size and accelerated parasite clearance. Cells from p110D910A mice were significantly impaired in their ability to make cytokines, particularly IFN-gamma, interleukin-10, and TNF, phenotypes, overview	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6 mice, BALB/c mice, and CB-17/lcr-Prkdcscid/Crl, i.e. BALB/c SCID, mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B-lymphocyte	-	Mus musculus	-
bone marrow cell	-	Mus musculus	-
femur	-	Mus musculus	-
L-929 cell	-	Mus musculus	-
leukocyte	-	Mus musculus	-
macrophage	-	Mus musculus	-
tibia	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
PI3K	-	Mus musculus

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Release 2023.1 (January 2023)