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Literature summary for 2.7.1.153 extracted from

  • Martin, A.L.; Schwartz, M.D.; Jameson, S.C.; Shimizu, Y.
    Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase (2008), J. Immunol., 180, 2081-2088.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the p110gamma isoform of PI3K is activated by G protein-coupled receptors and regulates neutrophil and macrophage chemotaxis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of p110gamma knockout mice. p110gamma-deficient effector CD8 T cells exhibit impaired migration in vitro and exhibit reduced migration into the inflamed peritoneum following vaccinia virus challenge in vivo. Furthermore, p110gamma-/- mice exhibit reduced influx in response to virus-induced peritonitis and exhibit increased susceptibility to vaccinia virus infection when compared with wild-type mice, phenotype, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus C57BL/6
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Synonyms

Synonyms Comment Organism
PI3K
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Mus musculus

General Information

General Information Comment Organism
physiological function selective regulation of CD8 effector T cell migration by the p110gamma catalytic subunit isoform of phosphatidylinositol 3-kinase Mus musculus