Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the p110gamma isoform of PI3K is activated by G protein-coupled receptors and regulates neutrophil and macrophage chemotaxis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of p110gamma knockout mice. p110gamma-deficient effector CD8 T cells exhibit impaired migration in vitro and exhibit reduced migration into the inflamed peritoneum following vaccinia virus challenge in vivo. Furthermore, p110gamma-/- mice exhibit reduced influx in response to virus-induced peritonitis and exhibit increased susceptibility to vaccinia virus infection when compared with wild-type mice, phenotype, overview | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57BL/6 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | selective regulation of CD8 effector T cell migration by the p110gamma catalytic subunit isoform of phosphatidylinositol 3-kinase | Mus musculus |