Application | Comment | Organism |
---|---|---|
medicine | application of PI3K/Akt/mTOR inhibitors in T-cell acute lymphoblastic leukemia, T-ALL | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[4-(4-morpholinyl)thieno(3,2-d)pyrimidin-2-yl]-phenol | a p110 PI3K isoform selective inhibitor | Homo sapiens | |
5-[2,2-difluoro-benzo(1,3)-dioxol-5-ylmethylene]-thiazolidine-2,4-dione | a p110 PI3K isoform selective inhibitor | Homo sapiens | |
LY294002 | - |
Homo sapiens | |
PI-103 | a dual PI3K/mTOR inhibitor and a small synthetic molecule of the pyridofuropyrimidine class. PI-103 induces caspase activation and is cytotoxic to all T-cell acute lymphoblastic leukemia cell lines affecting PI3K/Akt/mTOR signaling, mechanism, overview | Homo sapiens | |
TGX-221 | a p110 PI3K isoform selective inhibitor | Homo sapiens | |
Wortmannin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PI3K generates phosphatidylinositol 3,4,5 trisphosphate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCRF-CEM cell | CEM-S cell | Homo sapiens | - |
CCRF-CEM cell | CEM-R cell | Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
MOLT-4 cell | - |
Homo sapiens | - |
T-cell acute lymphoblastic leukemia cell | all cell lines express the catalytic subunit isoforms p110alpha, p110beta, p110gamma, and p110delta | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PI3K generates phosphatidylinositol 3,4,5 trisphosphate | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | PI3K is formed by a catalytic subunit p110, occuring in four isoforms p110alpha, p110beta, p110gamma, and p110delta, and a regulatory subunit p85 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
about, versus p110beta PI3K | Homo sapiens | TGX-221 | |
0.00025 | - |
about, versus p110gamma PI3K | Homo sapiens | 5-[2,2-difluoro-benzo(1,3)-dioxol-5-ylmethylene]-thiazolidine-2,4-dione | |
0.00058 | - |
versus p110alpha PI3K | Homo sapiens | 3-[4-(4-morpholinyl)thieno(3,2-d)pyrimidin-2-yl]-phenol |
General Information | Comment | Organism |
---|---|---|
malfunction | constitutively activated phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin, mTOR, signaling is a common feature of T-cell acute lymphoblastic leukemia, where it strongly influences growth and survival | Homo sapiens |
metabolism | PI3K/Akt/mTOR signaling, overview | Homo sapiens |
physiological function | p110 isoforms alpha, beta, and gamma PI3K are involved in T-cell acute lymphoblastic leukemia cell survival, but not p110delta PI3K | Homo sapiens |