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Literature summary for 2.7.1.153 extracted from

  • Knowles, M.A.; Platt, F.M.; Ross, R.L.; Hurst, C.D.
    Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer (2009), Cancer Metastasis Rev., 28, 305-316.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.153

Activating Compound

Activating Compound Comment Organism Structure
additional information activated receptor tyrosine kinases recruit the PI3 kinase complex to the membrane via the p85 regulatory subunit either directly or via insulin receptor substrate adapter proteins, activating the catalytic subunit p110 Homo sapiens

Protein Variants

Protein Variants Comment Organism
A1066V a common naturally occuring mutation involved in cancer development Homo sapiens
D1017H a common naturally occuring somatic mutation involved in cancer development Homo sapiens
E542K a common naturally occuring mutation in the helical domain, the mutation is involved in cancer development, the mutant requires RAS binding but bot p85 binding Homo sapiens
E545K a common naturally occuring mutation in the helical domain, the mutation is involved in cancer development, the mutant requires RAS binding but bot p85 binding Homo sapiens
H1047R a common naturally occuring mutation of the kinase domain, that is involved in cancer development Homo sapiens
M1043I a common naturally occuring somatic mutation involved in cancer development Homo sapiens
additional information mutations in PIK3CA are also found commonly in the benign skin lesions seborrheic keratosis and epidermal nevi Homo sapiens
P124L a common naturally occuring somatic mutation involved in cancer development. P124L lies in a region of four helices in the protein between the adapter-binding and RAS-binding domains Homo sapiens
P124T a naturally occuring missense mutation in codon 124 from a colorectal cancer cell Homo sapiens
Q643R a common naturally occuring somatic mutation involved in cancer development Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
additional information activated receptor tyrosine kinases recruit the PI3 kinase complex to the membrane via the p85 regulatory subunit either directly or via insulin receptor substrate adapter proteins, activating the catalytic subunit p110 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate Homo sapiens
-
 ADP + phosphatidylinositol-3,4,5-trisphosphate i.e. PIP3, PIP3 recruits protein dependent kinase 1, PDK1, and AKT, also known as protein kinase B, PKB, to the plasma membrane ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
urinary bladder cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate
-
 Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate
-
 ?
ATP + phosphatidylinositol-4,5-bisphosphate
-
 Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate i.e. PIP3, PIP3 recruits protein dependent kinase 1, PDK1, and AKT, also known as protein kinase B, PKB, to the plasma membrane ?

Subunits

Subunits Comment Organism
dimer PI3 kinases are heterodimers comprised of a regulatory subunit p85 and a catalytic subunit p110. Class IA subunit p110, i.e. PIK3CA, exists in three isoforms, p110alpha, p110beta, and p110gamma. All have similar structure with domains for binding to the adaptor protein subunit PIK3R1, p85, and to RAS Homo sapiens

Synonyms

Synonyms Comment Organism
PI3K
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction aberrant activation of the phosphatidylinositol 3-kinase pathway is involved in a wide range of cancers. Mutations in subunit isoform p110alpha are involved in development of bladder cancer, and are also common in the benign skin lesions seborrheic keratosis and epidermal nevi Homo sapiens
metabolism the phosphatidylinositol 3-kinase pathway is a critical signal transduction pathway that regulatesmultiple cellular functions, class IA PI3K signalling pathway, overview Homo sapiens