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Literature summary for 2.7.1.153 extracted from

  • Maier, U.; Babich, A.; Nurnberg, B.
    Roles of non-catalytic subunits in Gbg-induced activation of class I phosphoinositide 3-kinase isoforms b and g (1999), J. Biol. Chem., 274, 29311-29317.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
G-protein beta,gamma subunits significant stimulation of enzyme beta and gamma isoforms in the presence as well as in the absence of non-catalytic subunits such as p85alpha or p101, stimulation of autophosphorylation of the catalytic subunit of enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens subunit p101 is responsible for phosphatidylinositol-4,5-bisphosphate substrate selectivity of enzyme gamma isoform by sensitizing p110 gamma toward G-protein beta,gamma-subunits in the presence of phosphatidylinositol-4,5-bisphosphate ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P48736 gamma isoform
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein stimulation of autophosphorylation of catalytic sunbunit by G-protein beta,gamma subunits Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information subunit p101 is responsible for phosphatidylinositol-4,5-bisphosphate substrate selectivity of enzyme gamma isoform by sensitizing p110 gamma toward G-protein beta,gamma-subunits in the presence of phosphatidylinositol-4,5-bisphosphate Homo sapiens ?
-
 ?