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Literature summary for 2.7.1.151 extracted from

  • Xu, R.; Snyder, S.
    Gene transcription by p53 requires inositol polyphosphate multikinase as a co-activator (2013), Cell Cycle, 12, 1819-1820.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.151

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ?
additional information Homo sapiens inositol polyphosphate multikinase is a multifunctional enzyme with PI3-kinase, IP3-kinase and catalytically independent activities. IPMK is a PI3-kinase which phosphorylates PIP2 into PIP3, serving as a physiologic activator of Akt/PKB. It also possesses IP3-kinase activity, converting IP3 into IP4 (1,3,4,5) or IP4 (1,4,5,6). Whether the phosphorylation of IP3 at the 3-position or the 6-position is physiologically regulated ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate
-
 ?
additional information inositol polyphosphate multikinase is a multifunctional enzyme with PI3-kinase, IP3-kinase and catalytically independent activities. IPMK is a PI3-kinase which phosphorylates PIP2 into PIP3, serving as a physiologic activator of Akt/PKB. It also possesses IP3-kinase activity, converting IP3 into IP4 (1,3,4,5) or IP4 (1,4,5,6). Whether the phosphorylation of IP3 at the 3-position or the 6-position is physiologically regulated Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
inositol polyphosphate multikinase
-
 Homo sapiens
IPMK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function IPMK is a pleiotropic enzyme. Gene transcription by p53 requires inositol polyphosphate multikinase as a co-activator. IPMK subsequently phosphorylates IP4 into IP5, and is the rate-limiting enzyme for this metabolite. IPMK serves as the gate-keeping enzyme for the synthesis of all higher inositol polyphosphate species, including inositol diphosphates, which are implicated in diverse physiologic processes. Independent of catalytic activity, IPMK binds to p53 and enhances its association with p300. The enhancement of p300s histone acetyltransferase activity by IPMK leads to increased acetylation of p53 and histone H3, as well as p53 association to target promoters. This augmentation of p53-dependent gene transcription enhances cell death. IPMK is also a major PI3 kinase, which acts together with the wortmannin-sensitive p110/p85 PI3 kinase, EC 2.7.1.153, to generatephosphatidylinositol-3,4,5-trisphosphate that activates Akt and protein synthesis. Both wild-type and catalytically inactive IPMK stabilize the mTOR-1 complex to facilitate protein translation Homo sapiens