BRENDA - Enzyme Database
show all sequences of 2.7.1.151

Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases

Saiardi, A.; Erdjument-Bromage, H.; Snowman, A.M.; Tempst, P.; Snyder, S.H.; Curr. Biol. 9, 1323-1326 (1999)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in HEK293 cells as glutathione S-transferase fusion protein
Saccharomyces cerevisiae
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol tetrakisphosphate + ATP
-
393220
Saccharomyces cerevisiae
myo-inositol pentakisphosphate + ADP
-
393220
Saccharomyces cerevisiae
?
myo-inositol triphosphate + ATP
-
393220
Saccharomyces cerevisiae
myo-inositol tetrakisphosphate + ADP
-
393220
Saccharomyces cerevisiae
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in HEK293 cells as glutathione S-transferase fusion protein
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol tetrakisphosphate + ATP
-
393220
Saccharomyces cerevisiae
myo-inositol pentakisphosphate + ADP
-
393220
Saccharomyces cerevisiae
?
myo-inositol triphosphate + ATP
-
393220
Saccharomyces cerevisiae
myo-inositol tetrakisphosphate + ADP
-
393220
Saccharomyces cerevisiae
?
Other publictions for EC 2.7.1.151
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739553
Ahmed
Huntingtons disease: neural dy ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
112
9751-9756
2015
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1
1
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5
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1
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2
2
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737989
Xu
Gene transcription by p53 requ ...
Homo sapiens
Cell Cycle
12
1819-1820
2013
-
-
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-
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1
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5
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1
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5
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5
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1
1
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739065
Wickramasinghe
Human inositol polyphosphate m ...
Homo sapiens
Mol. Cell
51
737-750
2013
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5
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3
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3
3
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739531
Xu
Inositol polyphosphate multiki ...
Mus musculus
Proc. Natl. Acad. Sci. USA
110
16181-16186
2013
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2
2
-
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-
739703
Xu
Inositol polyphosphate multiki ...
Homo sapiens
Sci. Signal.
6
ra22
2013
-
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1
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2
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1
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3
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1
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2
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2
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3
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2
2
-
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722781
Endo-Streeter
Structural studies and protein ...
Arabidopsis thaliana
J. Biol. Chem.
287
35360-35369
2012
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1
3
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8
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6
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3
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1
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8
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3
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8
8
723659
Bang
AMP-activated protein kinase i ...
Mus musculus
Proc. Natl. Acad. Sci. USA
109
616-620
2012
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2
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1
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1
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1
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1
1
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-
721987
Kim
Amino acid signaling to mTOR m ...
Mus musculus
Cell Metab.
13
215-221
2011
-
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1
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1
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1
1
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723641
Maag
Inositol polyphosphate multiki ...
Mus musculus
Proc. Natl. Acad. Sci. USA
108
1391-1396
2011
-
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1
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1
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1
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1
1
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-
706854
Zhang
Generation of selectable marke ...
Arabidopsis thaliana
Transgenic Res.
18
607-619
2009
-
1
1
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-
-
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3
-
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1
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686905
Resnick
Inositol polyphosphate multiki ...
Arabidopsis thaliana, Drosophila melanogaster, Homo sapiens, Rattus norvegicus, Saccharomyces cerevisiae, Solanum tuberosum
Front. Biosci.
13
856-866
2008
-
6
4
1
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1
-
6
-
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24
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6
-
6
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-
1
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24
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6
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6
4
6
1
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1
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6
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24
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6
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1
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24
-
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689562
Yang
Enhancement of stress toleranc ...
Arabidopsis thaliana
Plant Mol. Biol.
66
329-343
2008
1
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1
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2
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1
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8
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2
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1
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2
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671894
Caddick
A lysine accumulation phenotyp ...
Solanum tuberosum
Biochem. J.
403
381-389
2007
-
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1
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3
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1
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-
673015
Leyman
The absence of expression of t ...
Mus musculus
Cell. Signal.
19
1497-1504
2007
-
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-
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1
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3
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2
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1
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1
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2
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1
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-
674855
Gao
Inositol pentakisphosphate med ...
Mus musculus
J. Biol. Chem.
282
26490-26502
2007
-
-
-
-
-
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1
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3
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1
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1
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1
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-
689588
Zhang
Arabidopsis inositol polyphosp ...
Arabidopsis thaliana
Plant Physiol.
144
942-951
2007
1
-
1
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2
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3
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-
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7
-
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2
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1
-
1
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2
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7
-
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2
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660926
Chang
Inositol polyphosphate multiki ...
Homo sapiens
Biochem. Biophys. Res. Commun.
339
209-216
2006
-
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1
-
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-
-
8
-
2
-
4
-
3
-
-
-
-
-
-
1
-
14
-
1
-
-
-
1
-
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1
-
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-
1
1
-
-
-
-
-
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8
-
2
-
4
-
-
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-
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1
-
14
-
1
-
-
-
1
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-
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-
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-
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-
-
673651
Riley
On the contribution of stereoc ...
Homo sapiens
FEBS Lett.
580
324-330
2006
-
-
-
-
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-
2
1
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1
-
2
-
-
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3
-
-
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-
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2
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2
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2
2
2
1
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1
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-
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3
-
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-
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674718
Holmes
Crystal structure of inositol ...
Saccharomyces cerevisiae
J. Biol. Chem.
281
38109-38116
2006
-
-
1
1
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2
-
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661446
Xia
Inositol 1,4,5-trisphosphate 3 ...
Arabidopsis thaliana, Homo sapiens, Saccharomyces cerevisiae
Cell Res.
15
83-91
2005
2
-
-
-
-
-
-
-
3
2
-
9
-
8
-
1
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7
-
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9
3
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3
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2
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3
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3
2
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9
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1
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7
-
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9
3
-
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662346
Mayr
Antiproliferative plant and sy ...
Homo sapiens
J. Biol. Chem.
280
13229-13240
2005
-
-
1
-
1
-
6
4
1
2
-
2
1
5
-
-
1
-
-
-
2
-
2
-
1
-
-
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1
-
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1
-
-
5
-
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1
1
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1
-
5
6
-
4
1
2
-
2
1
-
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1
-
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2
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2
-
1
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1
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662391
Seeds
Molecular definition of a nove ...
Saccharomyces cerevisiae
J. Biol. Chem.
280
27654-27661
2005
-
-
1
-
1
-
-
-
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1
-
5
-
2
-
-
-
-
-
-
-
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6
-
1
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1
-
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1
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1
1
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1
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1
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5
-
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-
-
-
-
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6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
663233
Resnick
Inositol polyphosphate multiki ...
Rattus norvegicus, Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
102
12783-12788
2005
-
-
1
-
-
-
2
2
2
2
1
5
-
3
-
-
2
-
-
4
2
-
11
1
2
-
-
-
2
-
-
2
-
-
-
-
-
1
2
-
-
-
-
2
-
2
2
2
1
5
-
-
-
2
-
4
2
-
11
1
2
-
-
-
2
-
-
-
-
-
-
-
-
-
663241
Saiardi
Inositol pyrophosphates regula ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
102
1911-1914
2005
-
-
-
-
1
-
2
-
-
-
-
1
-
1
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-
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-
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1
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1
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2
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663252
Frederick
An essential role for an inosi ...
Mus musculus
Proc. Natl. Acad. Sci. USA
102
8454-8459
2005
-
-
1
-
1
-
-
-
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-
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1
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3
-
-
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-
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3
-
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2
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1
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1
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1
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3
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2
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-
640974
Chang
The human homolog of the rat i ...
Homo sapiens
J. Biol. Chem.
277
43836-43843
2002
-
-
1
-
-
-
-
4
-
1
-
2
-
4
-
-
1
-
-
-
1
-
7
-
1
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-
-
1
-
-
1
-
-
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-
1
1
-
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4
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