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Literature summary for 2.7.1.149 extracted from

  • Bulley, S.J.; Droubi, A.; Clarke, J.H.; Anderson, K.E.; Stephens, L.R.; Hawkins, P.T.; Irvine, R.F.
    In B cells, phosphatidylinositol 5-phosphate 4-kinase-alpha synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling (2016), Proc. Natl. Acad. Sci. USA, 113, 10571-10576 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.149

Protein Variants

Protein Variants Comment Organism
D272K kinase-dead mutant Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Gallus gallus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Gallus gallus
-
DT-40 cell
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Gallus gallus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Gallus gallus

Synonyms

Synonyms Comment Organism
phosphatidylinositol 5-phosphate 4-kinase-alpha
-
 Gallus gallus
PI5P4Kalpha isoform Gallus gallus

General Information

General Information Comment Organism
malfunction long-Term loss of isoform PI5P4Kalpha by gene disruption results in compromised Akt phosphorylation Gallus gallus
physiological function the enzyme is necessary for maintenance of normal plasma membrane phosphatidylinositol (3,4,5)-trisphosphate levels in DT-40 cells. The enzyme is an acute negative regulator of mammalian target of rapamycin complex 2 Gallus gallus