Literature summary for 2.7.1.149 extracted from

Lundquist, M.; Goncalves, M.; Loughran, R.; Possik, E.; Vijayaraghavan, T.; Yang, A.; Pauli, C.; Ravi, A.; Verma, A.; Yang, Z.; Johnson, J.; Wong, J.; Ma, Y.; Hwang, K.; Weinkove, D.; Divecha, N.; Asara, J.; Elemento, O.; Rubin, M.; Kimmelman, A.; Pause, A.
Phosphatidylinositol-5-phosphate 4-kinases regulate cellular lipid metabolism by facilitating autophagy (2018), Mol. Cell., 70, 531-544 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate	Mus musculus	-	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-
MEF cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate	-	Mus musculus	ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
phosphatidylinositol-5-phosphate 4-kinase	-	Mus musculus
PI5P4Kalpha	-	Mus musculus
Pip4k2a	-	Mus musculus
Pip4k2b	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	mice lacking both enzyme isoforms in the liver have a defect in the ability to catabolize lipid droplets following a period of fasting. Enzyme loss of both isoforms results in lipid droplets accumulation and autophagy defects in MEF cells. Enzyme loss modifies expression of lysosomal and mTORC1 genes and alters metabolism as well as increases transcription factor EB nuclear translocation and activity	Mus musculus
physiological function	the enzyme plays a critical role in autophagy in times of energy stress	Mus musculus

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Release 2023.1 (January 2023)