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Literature summary for 2.7.1.149 extracted from
- Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase (2011), Neurochem. Res., 36, 627-635.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| quantitative real-time PCR expression analysis, expression of isozyme PIPKIIalpha in Xenopus laevis oocytes | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| photoreceptor inner segment | - |
Rattus norvegicus | 1917 | - |
| photoreceptor outer segment | - |
Mus musculus | 1750 | - |
| photoreceptor outer segment | - |
Rattus norvegicus | 1750 | - |
| photoreceptor outer segment membrane | - |
Mus musculus | 42622 | - |
| photoreceptor outer segment membrane | - |
Rattus norvegicus | 42622 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Mus musculus |  |
| Mg2+ | required | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Mus musculus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Rattus norvegicus | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Rattus norvegicus Sprague-Dawley | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Rattus norvegicus Sprague-Dawley | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | - |
Mus musculus | - |
| eye | - |
Rattus norvegicus | - |
| additional information | light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the ROS membrane | Mus musculus | - |
| additional information | light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the ROS membrane | Rattus norvegicus | - |
| photoreceptor cell | quantitative real-time PCR enzyme expression analysis | Mus musculus | - |
| retina | - |
Rattus norvegicus | - |
| retina | quantitative real-time PCR enzyme expression analysis | Mus musculus | - |
| retinal rod | inner segment | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Mus musculus | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Rattus norvegicus | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
| ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Rattus norvegicus Sprague-Dawley | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PIPKIIalpha | - |
Mus musculus |
| PIPKIIalpha | - |
Rattus norvegicus |
| type II alpha phosphatidylinositol-5-phosphate 4-kinase | - |
Mus musculus |
| type II alpha phosphatidylinositol-5-phosphate 4-kinase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | two subfamilies of phosphatidylinositol 5-phosphate 4-kinase kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell | Mus musculus |
| evolution | two subfamilies of phosphatidylinositol 5-phosphate 4-kinases produce 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate from independent pools of substrates. In addition, type I and II subfamilies of PIPK can localize in different subcellular compartments and are involved in the synthesis of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in distinct sites within cell | Rattus norvegicus |
| physiological function | greater type II alpha PIP kinase activity in the light-adapted rod outer segment membrane results from light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the rod outer segment membrane, thus improving access of the kinase to its lipid substrates. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase | Mus musculus |
| physiological function | greater type II alpha PIP kinase activity in the light-adapted rod outer segment membrane results from light-driven translocation of PIPKIIalpha from the rod inner segment to rod outer segment, and subsequent binding to the rod outer segment membrane, thus improving access of the kinase to its lipid substrates. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II alpha phosphatidylinositol-5-phosphate 4-kinase | Rattus norvegicus |
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