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Literature summary for 2.7.1.149 extracted from

  • Kouchi, Z.; Fujiwara, Y.; Yamaguchi, H.; Nakamura, Y.; Fukami, K.
    Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells (2011), Biochem. Biophys. Res. Commun., 408, 523-529.
    View publication on PubMed
Search for more literature for 2.7.1.149

Application

Application Comment Organism
medicine phosphatidylinositol-5-phosphate 4-kinase type II beta might be an effective therapeutic target for preventing of colon cancer progression Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of EGFP-tagged isozymes PIPKIIbeta and PIPKIIalpha in SW480-ADH cells cytosol and nucleus or cytosol, respectively Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information PIPKIIbeta knockdown Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PIPKIIbeta and PIPKIIalpha Homo sapiens 5829
-
nucleus PIPKIIbeta Homo sapiens 5634
-
plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol-5-phosphate 4-kinase type II beta
-
 Homo sapiens
PIPKIIbeta
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction phosphatidylinositol-5-phosphate 4-kinase type II beta knockdown inhibits E-cadherin upregulation induced by the vitamin D3 metabolite 1alpha,25(OH)2D3, while phosphatidylinositol-5-phosphate 4-kinase type II alpha does not Homo sapiens
physiological function the enzyme is required for vitamin D receptor-mediated E-cadherin induction in SW480-ADH cells expressing the vitamin D receptor. The enzyme is also involved in the suppression of the cell motility induced by 1alpha,25-dihydroxyvitamin D3, PIPKIIbeta inhibits the migratory activity of SW480-ADH cells. PIPKIIbeta-mediated phosphatidylinositol-4,5-bisphosphate signaling is important for E-cadherin upregulation and inhibition of cellular motility induced by vitamin D receptor activation. PIPKIIbeta but not PIPKIIalpha promotes E-cadherin upregulation in the presence of 1alpha,25(OH)2D3, overview Homo sapiens