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Literature summary for 2.7.1.149 extracted from

  • Itoh, T.; Ijuin, T.; Takenawa, T.
    A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals (1998), J. Biol. Chem., 273, 20292-20299.
    View publication on PubMed
Search for more literature for 2.7.1.149

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in COS-7 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
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 Rattus norvegicus 5783
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Rattus norvegicus the enzyme may have an important role in synthesis of phosphatidylinositol bisphosphate in the endoplasmic reticulum ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 enzyme form PIPKIIgamma
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein enzyme PIPKIIgamma is phosphorylated in vivo. Phosphorylation is induced by treatment of mitogens such as serum and epidermal growth factor Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
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fibroblast
-
 Rattus norvegicus
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kidney
-
 Rattus norvegicus
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PC-12 cell
-
 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate the enzyme may have an important role in synthesis of phosphatidylinositol bisphosphate in the endoplasmic reticulum Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?