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Literature summary for 2.7.1.145 extracted from
- Gemcitabine resistance in triple-negative breast cancer cells can be reverted by Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol (2020), Oncol. Lett., 20, 247 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is a potential candidate for reversing acquired gemcitabine resistance in triplex1enegative breast cancer cells, which may form the basis of strategies for the treatment of patients with drugx1eresistant triplex1enegative breast cancer | Drosophila melanogaster |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in MDA-MB-231 and MDA-MB-231R cells | Drosophila melanogaster |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a 2'-deoxyribonucleoside | Drosophila melanogaster | - |
ADP + a 2'-deoxyribonucleoside 5'-phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a 2'-deoxyribonucleoside | - |
Drosophila melanogaster | ADP + a 2'-deoxyribonucleoside 5'-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| deoxyribonucleoside kinase | - |
Drosophila melanogaster |
| dNK | - |
Drosophila melanogaster |
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