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Literature summary for 2.7.1.145 extracted from

  • Krawiec, K.; Kierdaszuk, B.; Kalinichenko, E.N.; Rubinova, E.B.; Mikhailopulo, I.A.; Eriksson, S.; Munch-Petersen, B.; Shugar, D.
    Ability of adenosine-2'(3')-deoxy-3'(2')-triphosphates and related analogues to replace ATP as phosphate donor for all human and Drosphila melanogaster deoxyribonucleoside kinases (2003), Nucleosides Nucleotides Nucleic Acids, 22, 1525-1529.
    View publication on PubMed
Search for more literature for 2.7.1.145

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7
-
 substrates 2'-deoxyadenosine and ATP Drosophila melanogaster
3
-
 substrates 2'-deoxycytidine and ATP Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-2'-fluoroadenosine 3'-triphosphate + 2'-deoxyadenosine low activity Drosophila melanogaster 2'-deoxy-2'-fluoroadenosine 3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
adenosine-2'-deoxy-2'-fluoro-3'-triphosphate + 2'-deoxycytidine low activity Drosophila melanogaster adenosine-2'-deoxy-2'-fluoro-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
adenosine-2'-deoxy-3'-triphosphate + 2'-deoxyadenosine low activity Drosophila melanogaster adenosine-2'-deoxy-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
adenosine-2'-deoxy-3'-triphosphate + 2'-deoxycytidine low activity Drosophila melanogaster adenosine-2'-deoxy-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
adenosine-3'-deoxy-2'-triphosphate + 2'-deoxyadenosine low activity Drosophila melanogaster adenosine-3'-deoxy-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
adenosine-3'-deoxy-2'-triphosphate + 2'-deoxycytidine low activity Drosophila melanogaster adenosine-3'-deoxy-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
adenosine-3'-deoxy-3'-fluoro-2'-triphosphate + 2'-deoxycytidine low activity Drosophila melanogaster adenosine-3'-deoxy-3'-fluoro-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + 2'-deoxyadenosine
-
 Drosophila melanogaster ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
ATP + 2'-deoxycytidine
-
 Drosophila melanogaster ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
additional information no activity with adenosine-3'-deoxy-3'-fluoroxylo-2'-triphosphate and adenosine-2'-deoxy-3'-fluoroara-3'-triphosphate as phosphate donors Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
dNK
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
2'-deoxy-2'-fluoroadenosine 3'-triphosphate 0.2-0.6% of the activity with ATP, dependent on the nucleoside substrate Drosophila melanogaster
adenosine-2'-deoxy-3'-triphosphate 0.5-1% of the activity with ATP, dependent on the nucleoside substrate Drosophila melanogaster
adenosine-3'-deoxy-2'-triphosphate 6-10% of the activity with ATP, dependent on the nucleoside substrate Drosophila melanogaster
adenosine-3'-deoxy-3'-fluoro-2'-triphosphate 0.2% of the activity with ATP and 2'deoxycytidine, no activity with 2'-deoxyadenosine Drosophila melanogaster
ATP
-
 Drosophila melanogaster