Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-[2-(benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13,7] decane-1-carboxamide | NVP-231 | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | Mus musculus | - |
ADP + ceramide 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8K4Q7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mesenchymal stem cell | bone marrow-derived mesenchymal stem cells, BM-MSCs | Mus musculus | - |
ST-2 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | - |
Mus musculus | ADP + ceramide 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CERK | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | a specific inhibitor of ceramide kinase inhibits TGF-beta-induced migration of BM-MSCs and N-cadherin that is necessary for BM-MSCs migration in response to TGF-beta | Mus musculus |
physiological function | endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor beta (TGF-beta). Extracellular bioactive lipid metabolites such as ceramide 1-phosphate and sphingosine 1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-beta. Ceramide kinase mediates the chemotactic migration of BM-MSCs in response to SP, SDF-1, or TGF-beta. Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells. The extracellular ceramide 1-phosphate regulates the migration of bone marrowderived multipotent mesenchymal stem cells (BM-MSCs) as well as macrophages, lung cancer cells, prostate cancer cells, and endothelial cells. Ceramide 1-phosphate generated by ceramide kinase is released extracellularly in order to induce cellular migration. Ceramide 1-phosphate also remains inside of cells in order to recruit cytosolic proteins and transduce signals. Ceramide kinase also regulates the expression of N-cadherin that is required for BM-MSCs migration induced by TGF-beta | Mus musculus |