Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a therapeutical target in breast cancer treatment due to its functional role in breast cancer recurrence | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | Homo sapiens | - |
ADP + ceramide 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TCT0 | gene CERK | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | CERK expression is associated with an increased risk of recurrence in women with breast cancer | Homo sapiens | - |
BT-20 cell | - |
Homo sapiens | - |
BT-474 cell | - |
Homo sapiens | - |
SKBR-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ceramide | - |
Homo sapiens | ADP + ceramide 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CERK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Cerk is rapidly upregulated in tumor cells following HER2/neu downregulation or treatment with adriamycin | down |
General Information | Comment | Organism |
---|---|---|
physiological function | ceramide kinase promotes tumor cell survival and mammary tumor recurrence. Ceramide kinase is required for mammary tumor recurrence following HER2/neu pathway inhibition and is spontaneously upregulated during tumor recurrence in multiple genetically engineered mouse models for breast cancer. CERK expression is associated with an increased risk of recurrence in women with breast cancer, Cerk promotes tumor cell survival in vivo | Homo sapiens |