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Literature summary for 2.7.1.138 extracted from

  • Bini, F.; Frati, A.; Garcia-Gil, M.; Battistini, C.; Granado, M.; Martinesi, M.; Mainardi, M.; Vannini, E.; Luzzati, F.; Caleo, M.; Peretto, P.; Gomez-Munoz, A.; Meacci, E.
    New signalling pathway involved in the anti-proliferative action of vitamin D3 and its analogues in human neuroblastoma cells. A role for ceramide kinase (2012), Neuropharmacology, 63, 524-537.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1alpha,25-dihydroxyvitamin D3 enzyme activity decreases by approximately 40% in the presence of the hormone Homo sapiens
ZK191784 enzyme activity decreases by approximately 25% in the presence of the hormone analogue Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TCT0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
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Homo sapiens
-

Synonyms

Synonyms Comment Organism
CERK
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of the enzyme, after 24 h of treatment with 1alpha,25-dihydroxyvitamin D3 or its analogue ZK191784, is reduced by approximately 40 and 60%, respectively down

General Information

General Information Comment Organism
physiological function ceramide kinase/ceramide 1-phosphate axis acts as molecular effector of the anti-proliferative action of 1alpha,25-dihydroxyvitamin D3 and its analogues. The inhibition of ceramide kinase by specific gene silencing or pharmacological inhibition, drastically reduces cell proliferation. 1alpha,25-Dihydroxyvitamin D3 and structural analogue ZK191784 treatment induce a significant decrease in ceramide kinase expression and ceramide 1-phosphate content, and an increase of ceramide. The treatment of SH-SY5Y cells with ZK159222, antagonist of 1alpha,25-dihydroxyvitamin D3 receptor, trichostatin A, inhibitor of histone deacetylases, and COUP-TFI-siRNA prevents the decrease of ceramide kinase expression elicited by 1alpha,25-dihydroxyvitamin D3 supporting the involvement of VDR/COUP-TFI/histone deacetylase complex in ceramide kinase regulation Homo sapiens