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Literature summary for 2.7.1.138 extracted from

  • Van Overloop, H.; Van Veldhoven, P.P.
    Ceramide-dependent release of ceramide kinase from cultured cells (2007), Biochem. Biophys. Res. Commun., 364, 169-174.
    View publication on PubMed
Search for more literature for 2.7.1.138

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information CERK can respond to stimuli by changing its localization, e.g. from Golgi to plasma membrane upon osmotic swelling, explaining perhaps the conflicting subcellular findings Cricetulus griseus
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plasma membrane CHO cell Cricetulus griseus 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + ATP Cricetulus griseus CERK and its product Cer-1-P are implicated in signaling processes, Cer-1-P stimulates DNA synthesis ceramide 1-phosphate + ADP
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 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
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 Cricetulus griseus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 the specific CERK activity in cells exposed for 16-18 h to 0.005 mM C6-ceramide dropped to 18.7% Cricetulus griseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + ATP
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 Cricetulus griseus ceramide 1-phosphate + ADP
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 ?
ceramide + ATP CERK and its product Cer-1-P are implicated in signaling processes, Cer-1-P stimulates DNA synthesis Cricetulus griseus ceramide 1-phosphate + ADP
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 ?
D-erythro-N-hexanoyl-sphingenine + ATP D-erythro isomer of C6-ceramide, the specific CERK activity in cells exposed for 16-18 h to 0.005 mM C6-ceramide dropped to 18.7% Cricetulus griseus D-erythro-N-hexanoyl-sphingenine 1-phosphate + ADP
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 ?
D-threo-C6-ceramide + ATP no or only weakly decrease of the specific CERK activity Cricetulus griseus D-threo-C6-ceramide 1-phosphate + ADP
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L-erythro-C6-ceramide + ATP no or only weakly decrease of the specific CERK activity Cricetulus griseus L-erythro-C6-ceramide 1-phosphate + ADP
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L-threo-C6-ceramide + ATP no or only weakly decrease of the specific CERK activity Cricetulus griseus L-threo-C6-ceramide 1-phosphate + ADP
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N-hexanoyl-sphinganine + ATP C6-dihydroceramide Cricetulus griseus N-hexanoyl-sphinganine 1-phosphate + ADP
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N-octyl-sphingenine + ATP C8-ceramine, no or only weakly decrease of the specific CERK activity Cricetulus griseus N-octyl-sphingenine 1-phosphate + ADP
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 ?

Synonyms

Synonyms Comment Organism
CERK
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 Cricetulus griseus