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Literature summary for 2.7.1.138 extracted from
- A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides (2008), Anal. Biochem., 384(1), 166-169.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| stable expression of human CerK in COS-1 cell, named COS-CerK cell, and RBL-2H3 cell | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NVP-231 | diamino-benzothiazole derivative, potent inhibitor, no inhibition with its analog NVP-995 | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ceramide + ATP | Homo sapiens | involvement in inflammatory processes and cell growth | ceramide 1-phosphate + ADP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8TCT0 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| C2-ceramide + ATP | C2-Cer is a potent inducer of cell death in CerK-expressing cells | Homo sapiens | C2-ceramide 1-phosphate + ADP | - |
? | |
| ceramide + ATP | - |
Homo sapiens | ceramide 1-phosphate + ADP | - |
? | |
| ceramide + ATP | involvement in inflammatory processes and cell growth | Homo sapiens | ceramide 1-phosphate + ADP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CERK | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000012 | - |
- |
Homo sapiens | NVP-231 | |
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Release 2023.1 (January 2023)
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