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Literature summary for 2.7.1.137 extracted from
- Subcellular Localization of PI3P in Arabidopsis (2020), Methods Mol. Biol., 2177, 109-118 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-Methyladenine | 3-MA, a nonspecific inhibitor of PI 3-kinases | Arabidopsis thaliana |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endosome | late | Arabidopsis thaliana | 5768 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Arabidopsis thaliana | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | Arabidopsis thaliana | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | P42339 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| root | - |
Arabidopsis thaliana | - |
| root tip | - |
Arabidopsis thaliana | - |
| seed | - |
Arabidopsis thaliana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Arabidopsis thaliana | ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol 3-kinase | - |
Arabidopsis thaliana |
| PI 3-kinase | - |
Arabidopsis thaliana |
| vacuolar protein sorting 34 | - |
Arabidopsis thaliana |
| VPS34 | - |
Arabidopsis thaliana |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Arabidopsis thaliana | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Arabidopsis thaliana pollen development is abnormal in knockout mutants for shared components of two VPS34 complexes (VPS34, VPS15, and ATG6/VPS30) | Arabidopsis thaliana |
| additional information | in yeast and mammals, Vps34 homologues are found in at least two distinct PI 3-kinase complexes. The Vps34 complex I, consisting of Vps34, Vps15, autophagy-related 6 (Atg6)/Vps30, and Atg14, regulates an early step of autophagy at the site of autophagosome formation, whereas the Vps34 complex II containing Vps34, Vps15, Atg6/ Vps30, and Vps38 (or UVRAG in mammals) is involved in vacuolar protein sorting and localized to the endosome | Arabidopsis thaliana |
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