Protein Variants | Comment | Organism |
---|---|---|
D743N | kinase-dead catalytic loop mutant | Homo sapiens |
L750M | mutation in the ATP-binding pocket. Mutant is less sensitive to inhibition by KU55933 than wild-type, mutant is similarly sensitive to inhibition by LY294002 as wild-type | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GΓΆ6976 | inhibitor directly targets phosphatidylinositol 3-kinase and confers profound inhibition of autophagic flux by inhibiting the formation of autophagosomes. It does not inhibit the cell survival promoting class I phosphoinositide 3-kinase-Akt signaling at the concentrations required for effective autophagy inhibition | Homo sapiens | |
KU55933 | inhibitor directly targets phosphatidylinositol 3-kinase and confers profound inhibition of autophagic flux by inhibiting the formation of autophagosomes. Inhibits wild-type activity in vitro almost as efficiently as LY294002. It does not inhibit the cell survival promoting class I phosphoinositide 3-kinase-Akt signaling at the concentrations required for effective autophagy inhibition | Homo sapiens | |
LY294002 | inhibits wild-type activity in vitro almost as efficiently as KU55933, but is required at much higher concentrations for efficient inhibition of autophagy | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NEB9 | catalytic subunit type 3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
VPS34 | - |
Homo sapiens |