Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p38 mitogen-activated protein kinase | activates PI3K, and proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation in retinal piment epithelial cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ARPE-19 cell | - |
Homo sapiens | - |
retinal pigment epithelium cell line | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | a signaling network regulates interleukin-8 production in response to proteasome activation or inactivation also involving PI3K, detailed overview | Homo sapiens |
physiological function | PI3K activity is involved in interleukin-8 production in retinal pigment epithelial cells, independent of 3-phosphoinositide-dependent protein kinase 1, PDK1, and Akt | Homo sapiens |