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Literature summary for 2.7.1.137 extracted from

  • Son, G.; Hines, I.N.; Lindquist, J.; Schrum, L.W.; Rippe, R.A.
    Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis (2009), Hepatology, 50, 1512-1523.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information expression of a dominant negative enzyme mutant under control of the smooth muscle alpha-actin promoter in murine hepatic stellate cells using transfection via an adenoviral vector, Ad-SMAdnPI3K, results in reduced HSC activation and decreased extracellular matrix deposition, including collagen expression. A reduction in profibrogenic mediators, including transforming growth factor beta, tissue inhibitor of metalloproteinase 1, and connective tissue growth factor also occurs, however, liver damage, assessed by alanine aminotransferase levels, is not reduced Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatic stellate cell a primary cell type in the liver responsible for excess collagen deposition during fibrosis Mus musculus
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liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
PI3K
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction phosphatidylinositol 3-kinase signaling is involved in progression of hepatic fibrosis in hepatic stellate cells. Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells, by either a pharmacological or by a genetic approach, blocks the progression of hepatic fibrosis inhibiting extracellular matrix deposition, including synthesis of type I collagen, and reducing expression of profibrogenic factors, mechanism, overview. Inhibition of PI3K signaling is also associated with reduced activation of Akt, p70 S6 kinase, and extracellular regulated kinase signaling as well as reduced cyclin D1 expression Mus musculus
physiological function the PI3K signaling pathway regulates several aspects of hepatic stellate cell activation in vitro, including collagen synthesis and cell proliferation, overview. Inhibition of PI3K decreases expression of alpha1(I)collagen in hepatic stellate cells mediated in part by inhibiting gene transcription, mechanism, overview Mus musculus