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Literature summary for 2.7.1.137 extracted from

  • Wu, J.; Wrathall, J.R.; Schachner, M.
    Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes (2010), Glia, 58, 315-328.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.137

Application

Application Comment Organism
drug development reduction of PI3K/PKCdelta activity represents a therapeutic target to downregulate adhesion molecule L1, CHL1, expression and thus benefit axonal regeneration after spinal cord injury Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
LY294002 a PI3K antagonist Mus musculus
PI3Kalpha inhibitor IV
-
 Mus musculus
PI3Kbeta inhibitor VI i.e. TGX-221 Mus musculus
PI3Kgamma inhibitor
-
 Mus musculus
Wortmannin a PI3K antagonist Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-
brain
-
 Mus musculus
-
cell culture of astrocytes from cerebral cortices Mus musculus
-

Synonyms

Synonyms Comment Organism
PI3K
-
 Mus musculus
PI3Kalpha
-
 Mus musculus
PI3Kbeta
-
 Mus musculus
PI3Kgamma
-
 Mus musculus

General Information

General Information Comment Organism
malfunction upregulation of expression of the close homologue of adhesion molecule L1, CHL1, by reactive astrocytes in the glial scar requires the activation of PI3K/PKCdelta-dependent pathways reduces axonal regeneration and inhibits functional recovery after spinal cord injury, overview Mus musculus
physiological function PI3K is involved in LPS-induced signaling in glial cells inducing the lipopolysaccharide-stimulated expression of adhesion molecule L1, CHL1. PI3K/PKCdelta-mediated nuclear translocation of NF-kappaB Mus musculus