Literature summary for 2.7.1.137 extracted from

Zhao, L.; Vogt, P.K.
Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (PI3K): Differential interactions with the regulatory subunit p85 and with RAS (2010), Cell Cycle, 9, 596-600.

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Cloned(Commentary)

Cloned (Comment)	Organism
genotyping	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	identification of hot-spot mutations in gene PIK2CA encoding the catalytic subunit p110alpha of PI3K, gain-of-function mutations allowing the mutant enzyme to constitutvely activate AKT signaling and induce oncogenic transformation in vitro and in vivo, the mutations lead to exchanges in the helical and kinase domains, overview. The gain of function induced by helical domain mutations require RAS-Gtp binding, while the kinase domain mutation is active in absence of RAS-Gtp binding, but depends on the interaction with p85, moleculr mechanisms, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene PIK3CA encoding the catalytic subunit p110alpha of PI3K	-

Synonyms

Synonyms	Comment	Organism
PI3K	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	gene PIK3CA, encoding the catalytic subunit p110alpha of PI3K, is mutated in about 12% of all human cancers, as single point mutations of hot-spot mutation with exchange of three positions, overview	Homo sapiens
physiological function	the enzyme activates Akt signaling	Homo sapiens

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Release 2023.1 (January 2023)