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Literature summary for 2.7.1.137 extracted from

  • Baryawno, N.; Sveinbjoernsson, B.; Eksborg, S.; Chen, C.S.; Kogner, P.; Johnsen, J.I.
    Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth (2010), Cancer Res., 70, 266-276.
    View publication on PubMed
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Application

Application Comment Organism
drug development the PI3K/Akt signaling pathway is a therapeutic target in treatment of medulloblastoma disease, a primitive neuroectodermal tumor, and the most common malignant pediatric brain tumor Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. The inhibitors affect beta-catenin signaling by inhibition of GSK-3beta activity, resulting in cytoplasmic retention of beta-catenin and reduced expression of its target genes cyclin D1 and c-Myc Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 clinical samples from Schwedish patients
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
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medulloblastoma cell
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 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PI3K
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the phosphatidylinositol 3-kinase/Akt signaling pathway is crucial to sustain the pathophysiology of medulloblastoma, a primitive neuroectodermal tumor and the most common malignant pediatric brain tumor. Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. The inhibitors affect beta-catenin signaling by inhibition of GSK-3beta activity, resulting in cytoplasmic retention of beta-catenin and reduced expression of its target genes cyclin D1 and c-Myc Homo sapiens
metabolism the enzyme is part of the phosphatidylinositol 3-kinase/Akt signaling pathway Homo sapiens