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Literature summary for 2.7.1.137 extracted from
- Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794 (2007), J. Biol. Chem., 282, 18069-18082.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | AMP-activated protein kinase, activated by energy depletion, inhibits cell survival by binding to and phosphorylating insulin receptor substrate-1 at Ser-794. Phosphorylation of insulin receptor substrate-1 at this site inhibits phosphatidylinositol 3-kinase/Akt signaling, suppresses the mitochondrial membrane potential, and promotes apoptosis | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | AMP-activated protein kinase, activated by energy depletion, inhibits cell survival by binding to and phosphorylating insulin receptor substrate-1 at Ser-794. Phosphorylation of insulin receptor substrate-1 at this site inhibits phosphatidylinositol 3-kinase/Akt signaling, suppresses the mitochondrial membrane potential, and promotes apoptosis | Homo sapiens | ? | - |
? | |
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