Literature summary for 2.7.1.137 extracted from

Uchida, M.; Iwase, M.; Takaoka, S.; Yoshiba, S.; Kondo, G.; Watanabe, H.; Ohashi, M.; Nagumo, M.; Shintani, S.
Enhanced susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in oral squamous cell carcinoma cells treated with phosphatidylinositol 3-kinase inhibitors (2007), Int. J. Oncol., 30, 1163-1171.

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Application

Application	Comment	Organism
medicine	PI 3-K inhibitors may represent a novel strategy for overcoming resistance to TRAIL-mediated apoptosis in oral squamous cell carcinoma cell	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
LY294002	the inhibitor markedly suppresses phosphorylation of Akt and accelerates TRAIL-mediated apoptosis in oral squamous cell carcinoma cell	Homo sapiens
Wortmannin	the inhibitor markedly suppresses phosphorylation of Akt and accelerates TRAIL-mediated apoptosis in oral squamous cell carcinoma cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HSC-2 cell	-	Homo sapiens	-
NA cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)