Literature summary for 2.7.1.137 extracted from

Tamburini, J.; Chapuis, N.; Bardet, V.; Park, S.; Sujobert, P.; Willems, L.; Ifrah, N.; Dreyfus, F.; Mayeux, P.; Lacombe, C.; Bouscary, D.
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways (2008), Blood, 111, 379-382.

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Application

Application	Comment	Organism
medicine	dual inhibition of the mTORC1 complex and the IGF-1/IGF-1R/PI3K/Akt pathway in acute myeloid leukemia may enhance the efficacy of mTOR inhibitors in treatment of this disease	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
IC87114	-	Homo sapiens
LY294002	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)