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Literature summary for 2.7.1.137 extracted from

  • Huang, W.; Dedousis, N.; Bhatt, B.A.; O'Doherty, R.M.
    Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity (2004), J. Biol. Chem., 279, 21695-21700.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
leptin increases the activity by 183% in liver at 90 ng/ml, livers and enzymes of rats with diet-induced obesity are resistant to leptin Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Rattus norvegicus
Wortmannin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the lipid-lowering effect of leptin on livers from lean rats is mediated by the enzyme, diet-induced obesity abolishes the effect of leptin on the enzyme and the lipid level and causes leptin resistance ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the lipid-lowering effect of leptin on livers from lean rats is mediated by the enzyme, diet-induced obesity abolishes the effect of leptin on the enzyme and the lipid level and causes leptin resistance Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 3-kinase
-
 Rattus norvegicus
PI 3-kinase
-
 Rattus norvegicus