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Literature summary for 2.7.1.137 extracted from

  • Jones, D.R.; Paneda, C.; Villar, A.V.; Alonso, A.; Goni, F.M.; Butikofer, P.; Brodbeck, U.; Shepherd, P.R.; Varela-Nieto, I.
    Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases (2005), FEBS Lett., 579, 59-65.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 phosphatidylinositol-4,5-bisphosphate preferred free substrate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information enzyme and free or anchored glycosylated substrate meet in the submembrane space Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate Homo sapiens
-
 ADP + phosphatidylinositol-3,4,5-trisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphatidylinositol-4,5-bisphosphate
-
 Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate
-
 ?
ATP + phosphatidylinositol-4,5-bisphosphate from rat liver and bovine erythrocyte and brain, substrate specificities, free or membrane anchored, phosphorylated phosphatidylinositol is poorer substrate than nonphosphorlyated, overview Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 3-kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens