Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | insulin stimulates | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.009 mM, potentiates glucose-stimulated insulin secretion from MIN6 cells in vivo | Rattus norvegicus | |
LY303511 | the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.065 mM | Rattus norvegicus | |
additional information | no inhibition by 5,6-dichlorobenzimidazole | Rattus norvegicus | |
Wortmannin | specific inhibition, no blockage of whole-cell outward K+ currents | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | as MgATP2- | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
insulinoma cell | - |
Rattus norvegicus | - |
MIN-6 cell | insulinoma cell | Mus musculus | - |
pancreatic beta cell | - |
Rattus norvegicus | - |
pancreatic islet | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 3-kinase | - |
Rattus norvegicus |
PI3K | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | 7.3 | assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | as MgATP2- | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.009 | - |
the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.009 mM, potentiates glucose-stimulated insulin secretion from MIN6 cells in vivo | Rattus norvegicus | LY294002 | |
0.065 | - |
the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.065 mM | Rattus norvegicus | LY303511 |