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Literature summary for 2.7.1.137 extracted from
- Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase (1997), Bioorg. Med. Chem., 5, 65-74.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the wild-type p110 alpha protein in CHO cells | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 85000 | - |
1 * 85000 + 1 * 110000 | Homo sapiens |
| 110000 | - |
1 * 85000 + 1 * 110000 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | mitogenic signal transduction pathway mediated by P13K is dependent upon the enzymatic activity of the p110 alpha subunit of P13K | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P42336 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidylinositol | - |
Homo sapiens | ADP + phosphatidylinositol 3-phosphate | - |
? | |
| additional information | mitogenic signal transduction pathway mediated by P13K is dependent upon the enzymatic activity of the p110 alpha subunit of P13K | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 85000 + 1 * 110000 | Homo sapiens |
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Release 2023.1 (January 2023)
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