Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.137 extracted from

  • Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.
    Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity (1998), J. Biol. Chem., 273, 33082-33090.
    View publication on PubMed
Search for more literature for 2.7.1.137

Cloned(Commentary)

Cloned (Comment) Organism
class II phosphoinositide 3-kinase with a C2 domain, cloned from a U937 monocyte cDNA library, expression in mammalian and insect cells Homo sapiens
class II phosphoinositide 3-kinase, PI 3-kinase C2b, with a C2 domain is cloned from a U937 monocyte cDNA library and expressed in mammalian and insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Wortmannin at nanomolar levels Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ can use either MgATP2- or CaATP2- Homo sapiens
Mg2+ can use either MgATP2- or CaATP2- Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 class II phosphoinositide 3-kinase, PI 3-kinase C2b
-
Homo sapiens O00750
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture U937 monocyte Homo sapiens
-
cell culture U937 monocytes Homo sapiens
-
monocyte
-
 Homo sapiens
-
monocyte U937 monocyte Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + phosphatidylinositol 4,5-bisphosphate no activity Homo sapiens ADP + phosphatidylinositol 3,4,5-trisphosphate
-
 ?
ATP + phosphatidylinositol 4-phosphate
-
 Homo sapiens ADP + phosphatidylinositol 3,4-bisphosphate
-
 ?