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Literature summary for 2.7.1.127 extracted from
- Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice (2016), Adv. Biol. Regul., 62, 1-10 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of Itpkc-/- mice, a Itpkc knockout mouse model | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q7TS72 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| bronchial epithelial cell | - |
Mus musculus | - |
| ependymocyte | brain | Mus musculus | - |
| kidney | - |
Mus musculus | - |
| large intestine | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| additional information | cells positive for ITPKC in the studied tissues express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa), suggesting a role for ITPKC either in the development or the function of these specialized cellular structures. Tissue expression and localization study, overview | Mus musculus | - |
| renal proximal tubule cell | - |
Mus musculus | - |
| small intestine | - |
Mus musculus | - |
| spermatozoon | - |
Mus musculus | - |
| trachea | - |
Mus musculus | - |
| tracheal epithelium | MTEC | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mus musculus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| inositol 1,4,5-trisphosphate 3-kinase C | - |
Mus musculus |
| Ins(1,4,5)P3 3-kinase | - |
Mus musculus |
| Itpkc | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases family which phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate | Mus musculus |
| physiological function | cells positive for ITPKC in the studied tissues express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa), suggesting a role for ITPKC either in the development or the function of these specialized cellular structures | Mus musculus |
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Release 2023.1 (January 2023)
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