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Literature summary for 2.7.1.127 extracted from

  • Lee, D.; Lee, H.W.; Hong, S.; Choi, B.I.; Kim, H.W.; Han, S.B.; Kim, I.H.; Bae, J.Y.; Bae, Y.C.; Rhyu, I.J.; Sun, W.; Kim, H.
    Inositol 1,4,5-trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity (2012), J. Biol. Chem., 287, 15981-15995.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule isoform inositol 1,4,5-trisphosphate 3-kinase A is a microtubule-associated protein, and the N terminus of inositol 1,4,5-trisphosphate 3-kinase A is a critical region for direct binding to tubulin in dendritic shaft of hippocampal neurons. Protein kinase A phosphorylates residue Ser119 within inositol 1,4,5-trisphosphate 3-kinase A, leading to a significant reduction of microtubule binding affinity Rattus norvegicus 5874
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus P17105 isoform inositol 1,4,5-trisphosphate 3-kinase A
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein isoform inositol 1,4,5-trisphosphate 3-kinase A is phosphorylated at residue Ser119 by protein kinase A, leading to a significant reduction of microtubule binding affinity Rattus norvegicus