Literature summary for 2.7.1.127 extracted from

Marechal, Y.; Queant, S.; Polizzi, S.; Pouillon, V.; Schurmans, S.
Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells (2010), Immunobiology, 216, 103-109.

Search for more literature for 2.7.1.127

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	B2RXC2	isoform inositol 1,4,5-trisphosphate 3-kinase B	-

Synonyms

Synonyms	Comment	Organism
inositol 1,4,5-trisphosphate 3-kinase B	-	Mus musculus
Itpkb	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	isoform inositol 1,4,5-trisphosphate 3-kinase B is important for the control of Bim protein expression and B cell survival rather than for the control of B cell development from one stage to another. B cell receptor transgenic inositol 1,4,5-trisphosphate 3-kinase B-/- B cells exhibit an anergic phenotype with the notable exception of their enhanced antigen-induced calcium signalling. On a deleting H2-Kb genetic background, inositol 1,4,5-trisphosphate 3-kinase B is not essential for B cell receptor editing or negative selection	Mus musculus

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Release 2023.1 (January 2023)