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Literature summary for 2.7.1.127 extracted from

  • Jia, Y.; Loison, F.; Hattori, H.; Li, Y.; Erneux, C.; Park, S.Y.; Gao, C.; Chai, L.; Silberstein, L.E.; Schurmans, S.; Luo, H.R.
    Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis (2008), Proc. Natl. Acad. Sci. USA, 105, 4739-4744.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.127

Cloned(Commentary)

Cloned (Comment) Organism
generation of knock-out mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
 Mus musculus
-
hematopoietic stem cell inositol trisphosphate 3-kinase B gene is expressed in all hematopoietic stem/progenitor cell populations Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol trisphosphate 3-kinase B
-
 Mus musculus
InsP3KB
-
 Mus musculus

General Information

General Information Comment Organism
malfunction disruption of InsP3KB leads to impaired T cell and B cell development as well as hyperactivation of neutrophils, in InsP3KB null mice, the bone marrow granulocyte monocyte progenitor (GMP) population is expanded, and GMP cells proliferated significantly faster, neutrophil production in the bone marrow is enhanced, and the peripheral blood neutrophil count is also substantially elevated, neutrophil apoptotic death is enhanced in enzyme knock-out mice, disruption of enzyme promotes myeloid differentiation Mus musculus
physiological function physiological modulator of myelopoiesis, enzyme plays a crucial role in hematopoiesis Mus musculus