Activating Compound | Comment | Organism | Structure |
---|---|---|---|
12-O-tetradecanoyl phorbol 13-acetate | stimulating in presence of cAMP | Homo sapiens | |
12-O-tetradecanoyl phorbol 13-acetate | stimulating in presence of cAMP | Rattus norvegicus | |
Ca2+/CaM-dependent kinase II | i.e. CaMKII, activates the enzyme by phosphorylation at a Thr residue | Sus scrofa | |
Ca2+/CaM-dependent kinase II | i.e. CaMKII, activates the enzyme by phosphorylation of Thr311 | Homo sapiens | |
Ca2+/CaM-dependent kinase II | i.e. CaMKII, activates the enzyme by phosphorylation of threonine residue | Rattus norvegicus | |
Calmodulin | 2-3fold activation of isozyme IP33K-A and 7-8fold of isozyme IP33K-B, in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids | Homo sapiens | |
Calmodulin | isozyme IP33K-A: 3-6fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids, residues Ser156-Leu189 and Trp165 are required | Rattus norvegicus | |
Calmodulin | up to 20fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids | Sus scrofa | |
cAMP-dependent protein kinase | i.e. PKA, activates the enzyme by phosphorylation at a Ser residue | Sus scrofa | |
cAMP-dependent protein kinase | i.e. PKA, activates the enzyme by phosphorylation at a serine residue | Homo sapiens | |
cAMP-dependent protein kinase | i.e. PKA, activates the enzyme by phosphorylation at Ser109, simultaneous phosphorylation at SEr109 and Ser175 inactivates the enzyme | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
overexpression of enzyme D-IP3K1 leads to increased resistance of flies to H2O2, but not to paraquat-induced oxidative stress, due to a decreased 1D-myo-inositol 1,4,5-trisphosphate level | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Protein kinase C | negative regulatory function, phosphorylates the enzyme at a serine residue | Homo sapiens | |
Protein kinase C | negative regulatory function, phosphorylates the enzyme at Ser175, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme | Rattus norvegicus | |
Protein kinase C | negative regulatory function, phosphorylates the enzyme at a Ser residue | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | isozyme IP33K-C | Homo sapiens | 5737 | - |
cytoskeleton | isozymes IP33K-A and IP33K-B | Homo sapiens | 5856 | - |
endoplasmic reticulum | isozyme IP33K-B | Homo sapiens | 5783 | - |
plasma membrane | isozyme IP33K-B | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation by calmodulin in a Ca2+-dependent manner | Homo sapiens | |
Ca2+ | activation by calmodulin in a Ca2+-dependent manner | Sus scrofa | |
Ca2+ | isozyme IP33K-A: 3-6fold activation by calmodulin in a Ca2+-dependent manner | Rattus norvegicus | |
Mg2+ | - |
Drosophila melanogaster | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C | Homo sapiens |
50900 | - |
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C | Rattus norvegicus |
53500 | - |
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C | Homo sapiens |
74000 | - |
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C | Rattus norvegicus |
74500 | - |
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C | Rattus norvegicus |
75200 | - |
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Drosophila melanogaster | the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Sus scrofa | the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
additional information | Homo sapiens | the enzyme might be involved in brain development, memory, and learning | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme might be involved in brain development, memory, and learning | ? | - |
? | |
additional information | Drosophila melanogaster | the enzyme might be involved in oxidative damage resistance | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
isozymes IP33K-A, IP33K-B, and IP33K-C | - |
Rattus norvegicus | - |
isozymes IP33K-A, IP33K-B, and IP33K-C | - |
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a Ser residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating a Ser residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue | Sus scrofa |
phosphoprotein | phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a serine residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating at a serine residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of Thr311 | Homo sapiens |
phosphoprotein | phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at Ser175, cAMP-dependent protein kinase activates the enzyme by phosphorylating Ser109, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Sus scrofa | - |
brain | isozymes IP33K-A, IP33K-B, and IP33K-C | Rattus norvegicus | - |
epithelium | isozyme IP33K-C | Rattus norvegicus | - |
heart | isozymes IP33K-B, and IP33K-C | Rattus norvegicus | - |
lung | isozyme IP33K-B | Rattus norvegicus | - |
testis | isozymes IP33K-A, IP33K-B, and IP33K-C | Rattus norvegicus | - |
thymus | isozyme IP33K-B | Rattus norvegicus | - |
tongue | isozyme IP33K-C | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Drosophila melanogaster | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Sus scrofa | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview | Drosophila melanogaster | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview | Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview | Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview | Sus scrofa | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
additional information | the enzyme might be involved in brain development, memory, and learning | Homo sapiens | ? | - |
? | |
additional information | the enzyme might be involved in brain development, memory, and learning | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme might be involved in oxidative damage resistance | Drosophila melanogaster | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C | Homo sapiens |
? | x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C | Rattus norvegicus |
More | structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain | Drosophila melanogaster |
More | structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain | Homo sapiens |
More | structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain | Sus scrofa |
More | structure analysis, the isozyme A contains a F-actin binding domain, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
inositol 1,4,5-trisphosphate 3-kinase | - |
Drosophila melanogaster |
inositol 1,4,5-trisphosphate 3-kinase | - |
Homo sapiens |
inositol 1,4,5-trisphosphate 3-kinase | - |
Rattus norvegicus |
inositol 1,4,5-trisphosphate 3-kinase | - |
Sus scrofa |
IP3 3-kinase | - |
Drosophila melanogaster |
IP3 3-kinase | - |
Homo sapiens |
IP3 3-kinase | - |
Rattus norvegicus |
IP3 3-kinase | - |
Sus scrofa |
IP3K | - |
Drosophila melanogaster |
IP3K | - |
Homo sapiens |
IP3K | - |
Rattus norvegicus |
IP3K | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Drosophila melanogaster | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus | |
ATP | - |
Sus scrofa |