BRENDA - Enzyme Database
show all sequences of 2.7.1.127

Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations

Xia, H.J.; Yang, G.; Cell Res. 15, 83-91 (2005)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
12-O-tetradecanoyl phorbol 13-acetate
stimulating in presence of cAMP
Homo sapiens
12-O-tetradecanoyl phorbol 13-acetate
stimulating in presence of cAMP
Rattus norvegicus
Ca2+/CaM-dependent kinase II
i.e. CaMKII, activates the enzyme by phosphorylation at a Thr residue
Sus scrofa
Ca2+/CaM-dependent kinase II
i.e. CaMKII, activates the enzyme by phosphorylation of Thr311
Homo sapiens
Ca2+/CaM-dependent kinase II
i.e. CaMKII, activates the enzyme by phosphorylation of threonine residue
Rattus norvegicus
Calmodulin
2-3fold activation of isozyme IP33K-A and 7-8fold of isozyme IP33K-B, in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids
Homo sapiens
Calmodulin
isozyme IP33K-A: 3-6fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids, residues Ser156-Leu189 and Trp165 are required
Rattus norvegicus
Calmodulin
up to 20fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids
Sus scrofa
cAMP-dependent protein kinase
i.e. PKA, activates the enzyme by phosphorylation at a Ser residue
Sus scrofa
cAMP-dependent protein kinase
i.e. PKA, activates the enzyme by phosphorylation at a serine residue
Homo sapiens
cAMP-dependent protein kinase
i.e. PKA, activates the enzyme by phosphorylation at Ser109, simultaneous phosphorylation at SEr109 and Ser175 inactivates the enzyme
Rattus norvegicus
Cloned(Commentary)
Cloned (Commentary)
Organism
overexpression of enzyme D-IP3K1 leads to increased resistance of flies to H2O2, but not to paraquat-induced oxidative stress, due to a decreased 1D-myo-inositol 1,4,5-trisphosphate level
Drosophila melanogaster
Inhibitors
Inhibitors
Commentary
Organism
Structure
Protein kinase C
negative regulatory function, phosphorylates the enzyme at a serine residue
Homo sapiens
Protein kinase C
negative regulatory function, phosphorylates the enzyme at Ser175, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme
Rattus norvegicus
Protein kinase C
negative regulatory function, phosphorylates the enzyme at a Ser residue
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
isozyme IP33K-C
Homo sapiens
5737
-
cytoskeleton
isozymes IP33K-A and IP33K-B
Homo sapiens
5856
-
endoplasmic reticulum
isozyme IP33K-B
Homo sapiens
5783
-
plasma membrane
isozyme IP33K-B
Homo sapiens
5886
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
activation by calmodulin in a Ca2+-dependent manner
Homo sapiens
Ca2+
activation by calmodulin in a Ca2+-dependent manner
Sus scrofa
Ca2+
isozyme IP33K-A: 3-6fold activation by calmodulin in a Ca2+-dependent manner
Rattus norvegicus
Mg2+
-
Drosophila melanogaster
Mg2+
-
Homo sapiens
Mg2+
-
Rattus norvegicus
Mg2+
-
Sus scrofa
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
Homo sapiens
50900
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
Rattus norvegicus
53500
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
Homo sapiens
74000
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
Rattus norvegicus
74500
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
Rattus norvegicus
75200
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Drosophila melanogaster
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Homo sapiens
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Rattus norvegicus
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Sus scrofa
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
additional information
Homo sapiens
the enzyme might be involved in brain development, memory, and learning
?
-
-
?
additional information
Rattus norvegicus
the enzyme might be involved in brain development, memory, and learning
?
-
-
?
additional information
Drosophila melanogaster
the enzyme might be involved in oxidative damage resistance
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
isozymes IP33K-A, IP33K-B, and IP33K-C
-
Rattus norvegicus
-
isozymes IP33K-A, IP33K-B, and IP33K-C
-
Sus scrofa
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
phosphoprotein
phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a Ser residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating a Ser residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue
Sus scrofa
phosphoprotein
phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a serine residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating at a serine residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of Thr311
Homo sapiens
phosphoprotein
phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at Ser175, cAMP-dependent protein kinase activates the enzyme by phosphorylating Ser109, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Homo sapiens
-
brain
-
Sus scrofa
-
brain
isozymes IP33K-A, IP33K-B, and IP33K-C
Rattus norvegicus
-
epithelium
isozyme IP33K-C
Rattus norvegicus
-
heart
isozymes IP33K-B, and IP33K-C
Rattus norvegicus
-
lung
isozyme IP33K-B
Rattus norvegicus
-
testis
isozymes IP33K-A, IP33K-B, and IP33K-C
Rattus norvegicus
-
thymus
isozyme IP33K-B
Rattus norvegicus
-
tongue
isozyme IP33K-C
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
661446
Drosophila melanogaster
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
661446
Homo sapiens
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
661446
Rattus norvegicus
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
661446
Sus scrofa
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
661446
Drosophila melanogaster
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
661446
Homo sapiens
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
661446
Rattus norvegicus
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
661446
Sus scrofa
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
additional information
the enzyme might be involved in brain development, memory, and learning
661446
Homo sapiens
?
-
-
-
?
additional information
the enzyme might be involved in brain development, memory, and learning
661446
Rattus norvegicus
?
-
-
-
?
additional information
the enzyme might be involved in oxidative damage resistance
661446
Drosophila melanogaster
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
Homo sapiens
?
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
Rattus norvegicus
More
structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
Drosophila melanogaster
More
structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
Homo sapiens
More
structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
Sus scrofa
More
structure analysis, the isozyme A contains a F-actin binding domain, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
Rattus norvegicus
Synonyms
Synonyms
Commentary
Organism
inositol 1,4,5-trisphosphate 3-kinase
-
Drosophila melanogaster
inositol 1,4,5-trisphosphate 3-kinase
-
Homo sapiens
inositol 1,4,5-trisphosphate 3-kinase
-
Rattus norvegicus
inositol 1,4,5-trisphosphate 3-kinase
-
Sus scrofa
IP3 3-kinase
-
Drosophila melanogaster
IP3 3-kinase
-
Homo sapiens
IP3 3-kinase
-
Rattus norvegicus
IP3 3-kinase
-
Sus scrofa
IP3K
-
Drosophila melanogaster
IP3K
-
Homo sapiens
IP3K
-
Rattus norvegicus
IP3K
-
Sus scrofa
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Drosophila melanogaster
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
ATP
-
Sus scrofa
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
12-O-tetradecanoyl phorbol 13-acetate
stimulating in presence of cAMP
Homo sapiens
12-O-tetradecanoyl phorbol 13-acetate
stimulating in presence of cAMP
Rattus norvegicus
Ca2+/CaM-dependent kinase II
i.e. CaMKII, activates the enzyme by phosphorylation at a Thr residue
Sus scrofa
Ca2+/CaM-dependent kinase II
i.e. CaMKII, activates the enzyme by phosphorylation of Thr311
Homo sapiens
Ca2+/CaM-dependent kinase II
i.e. CaMKII, activates the enzyme by phosphorylation of threonine residue
Rattus norvegicus
Calmodulin
2-3fold activation of isozyme IP33K-A and 7-8fold of isozyme IP33K-B, in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids
Homo sapiens
Calmodulin
isozyme IP33K-A: 3-6fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids, residues Ser156-Leu189 and Trp165 are required
Rattus norvegicus
Calmodulin
up to 20fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids
Sus scrofa
cAMP-dependent protein kinase
i.e. PKA, activates the enzyme by phosphorylation at a Ser residue
Sus scrofa
cAMP-dependent protein kinase
i.e. PKA, activates the enzyme by phosphorylation at a serine residue
Homo sapiens
cAMP-dependent protein kinase
i.e. PKA, activates the enzyme by phosphorylation at Ser109, simultaneous phosphorylation at SEr109 and Ser175 inactivates the enzyme
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
overexpression of enzyme D-IP3K1 leads to increased resistance of flies to H2O2, but not to paraquat-induced oxidative stress, due to a decreased 1D-myo-inositol 1,4,5-trisphosphate level
Drosophila melanogaster
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Drosophila melanogaster
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
ATP
-
Sus scrofa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Protein kinase C
negative regulatory function, phosphorylates the enzyme at a Ser residue
Sus scrofa
Protein kinase C
negative regulatory function, phosphorylates the enzyme at a serine residue
Homo sapiens
Protein kinase C
negative regulatory function, phosphorylates the enzyme at Ser175, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
isozyme IP33K-C
Homo sapiens
5737
-
cytoskeleton
isozymes IP33K-A and IP33K-B
Homo sapiens
5856
-
endoplasmic reticulum
isozyme IP33K-B
Homo sapiens
5783
-
plasma membrane
isozyme IP33K-B
Homo sapiens
5886
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
activation by calmodulin in a Ca2+-dependent manner
Homo sapiens
Ca2+
activation by calmodulin in a Ca2+-dependent manner
Sus scrofa
Ca2+
isozyme IP33K-A: 3-6fold activation by calmodulin in a Ca2+-dependent manner
Rattus norvegicus
Mg2+
-
Drosophila melanogaster
Mg2+
-
Homo sapiens
Mg2+
-
Rattus norvegicus
Mg2+
-
Sus scrofa
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
Homo sapiens
50900
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
Rattus norvegicus
53500
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
Homo sapiens
74000
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
Rattus norvegicus
74500
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
Rattus norvegicus
75200
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Drosophila melanogaster
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Homo sapiens
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Rattus norvegicus
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
Sus scrofa
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
?
additional information
Homo sapiens
the enzyme might be involved in brain development, memory, and learning
?
-
-
?
additional information
Rattus norvegicus
the enzyme might be involved in brain development, memory, and learning
?
-
-
?
additional information
Drosophila melanogaster
the enzyme might be involved in oxidative damage resistance
?
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
phosphoprotein
phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a Ser residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating a Ser residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue
Sus scrofa
phosphoprotein
phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a serine residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating at a serine residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of Thr311
Homo sapiens
phosphoprotein
phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at Ser175, cAMP-dependent protein kinase activates the enzyme by phosphorylating Ser109, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Homo sapiens
-
brain
-
Sus scrofa
-
brain
isozymes IP33K-A, IP33K-B, and IP33K-C
Rattus norvegicus
-
epithelium
isozyme IP33K-C
Rattus norvegicus
-
heart
isozymes IP33K-B, and IP33K-C
Rattus norvegicus
-
lung
isozyme IP33K-B
Rattus norvegicus
-
testis
isozymes IP33K-A, IP33K-B, and IP33K-C
Rattus norvegicus
-
thymus
isozyme IP33K-B
Rattus norvegicus
-
tongue
isozyme IP33K-C
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
661446
Drosophila melanogaster
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
661446
Homo sapiens
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
661446
Rattus norvegicus
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
661446
Sus scrofa
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
661446
Drosophila melanogaster
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
661446
Homo sapiens
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
661446
Rattus norvegicus
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview
661446
Sus scrofa
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
-
-
?
additional information
the enzyme might be involved in brain development, memory, and learning
661446
Homo sapiens
?
-
-
-
?
additional information
the enzyme might be involved in brain development, memory, and learning
661446
Rattus norvegicus
?
-
-
-
?
additional information
the enzyme might be involved in oxidative damage resistance
661446
Drosophila melanogaster
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
Homo sapiens
?
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
Rattus norvegicus
More
structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
Drosophila melanogaster
More
structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
Homo sapiens
More
structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
Sus scrofa
More
structure analysis, the isozyme A contains a F-actin binding domain, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
Rattus norvegicus
Other publictions for EC 2.7.1.127
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737402
Erneux
Inositol(1,4,5)P3 3-kinase iso ...
Mus musculus, Rattus norvegicus, Homo sapiens
Adv. Biol. Regul.
60
135-143
2016
16
-
9
-
-
-
-
-
7
18
3
9
-
15
-
5
1
-
-
67
-
-
9
9
27
-
-
-
-
-
-
-
9
-
-
-
16
-
9
9
-
-
-
-
-
-
-
7
18
3
9
-
-
5
1
-
67
-
-
9
9
-
-
-
-
-
-
-
-
-
31
31
-
-
-
737403
Scoumanne
Specific expression and functi ...
Mus musculus
Adv. Biol. Regul.
62
1-10
2016
-
-
1
-
-
-
-
-
3
-
1
1
-
5
-
-
-
-
-
20
-
-
1
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
3
-
1
1
-
-
-
-
-
20
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
738022
Koester
Inositol-1,4,5-trisphosphate-3 ...
Mus musculus, Mus musculus C57BL/6
Cell. Signal.
28
83-90
2016
-
-
1
-
-
-
-
-
1
2
-
2
-
4
-
-
1
-
-
3
-
-
2
-
2
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
2
-
2
-
-
-
1
-
3
-
-
2
-
-
-
-
-
1
-
-
-
-
2
2
-
-
-
739679
Chung
The role of inositol 1,4,5-tri ...
Mus musculus, Mus musculus C57BL/6N
Sci. Rep.
6
23757
2016
-
-
1
-
-
-
-
-
1
2
-
2
-
8
-
-
-
-
-
3
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
2
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
738088
Ashour
The catalytic domain of inosit ...
Homo sapiens
Cytoskeleton (Hoboken)
72
93-100
2015
-
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
1
3
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
738216
Koenig
Regulation of NGF-driven neuri ...
Rattus norvegicus
FEBS J.
282
2553-2569
2015
-
-
-
-
3
-
-
-
3
3
-
3
-
5
-
-
-
-
-
6
-
-
3
-
6
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
3
-
-
-
-
-
3
3
-
3
-
-
-
-
-
6
-
-
3
-
-
-
-
-
-
-
-
-
-
8
8
-
-
-
737647
Franco-Echevarria
A new calmodulin-binding motif ...
Homo sapiens
Biochem. J.
463
319-328
2014
1
-
-
1
-
-
-
-
-
2
-
1
-
4
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737961
Stygelbout
Inositol trisphosphate 3-kinas ...
Mus musculus, Homo sapiens
Brain
137
537-552
2014
-
-
-
-
-
-
-
-
-
4
-
2
-
12
-
-
-
-
-
6
-
-
2
-
4
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737400
Pouillon
-
Inositol 1,4,5-trisphosphate 3 ...
Mus musculus
Adv. Biol. Regul.
53
39-50
2013
-
-
-
-
1
-
-
-
-
2
-
1
-
1
-
-
-
-
-
9
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
9
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
737593
Schroeder
Identification of a new membra ...
Homo sapiens
Biochem. Biophys. Res. Commun.
439
228-234
2013
-
-
1
-
-
-
4
1
-
1
-
1
-
1
-
-
1
-
-
3
-
-
1
-
2
1
-
-
-
1
-
-
1
-
-
3
-
-
1
1
-
-
-
3
4
-
1
-
1
-
1
-
-
-
1
-
3
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
722003
Windhorst
Inositol-1,4,5-trisphosphate 3 ...
Homo sapiens
Cell. Signal.
24
750-757
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722753
Lee
Inositol 1,4,5-trisphosphate 3 ...
Rattus norvegicus
J. Biol. Chem.
287
15981-15995
2012
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722735
Nalaskowski
Human inositol 1,4,5-trisphosp ...
Homo sapiens
J. Biol. Chem.
286
4500-4510
2011
-
-
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722002
Terhzaz
Cell-specific inositol 1,4,5 t ...
Drosophila melanogaster
Cell. Signal.
22
737-748
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
722381
Marechal
Inositol 1,4,5-trisphosphate 3 ...
Mus musculus
Immunobiology
216
103-109
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
699006
Windhorst
Inositol-1,4,5-trisphosphate-3 ...
Homo sapiens
J. Biol. Chem.
285
5541-5554
2009
1
-
3
-
1
-
1
-
-
-
-
1
-
7
-
-
1
-
-
13
2
-
1
-
3
-
-
-
-
1
-
-
-
-
-
1
1
-
3
-
-
1
-
1
1
-
-
-
-
-
1
-
-
-
1
-
13
2
-
1
-
-
-
-
-
1
-
-
-
4
2
2
4
-
-
699348
Miller
Inositol 1,4,5-trisphosphate 3 ...
Mus musculus
J. Immunol.
182
4696-4704
2009
-
-
1
-
-
-
-
-
-
1
-
1
-
7
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
699694
Kim
Inositol 1,4,5-trisphosphate 3 ...
Mus musculus, Rattus norvegicus
J. Neurosci.
29
14039-14049
2009
2
-
2
-
1
-
-
-
-
2
-
2
-
4
-
-
-
-
-
5
-
-
2
-
4
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
1
-
-
-
-
-
-
2
-
2
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
1
3
3
1
-
-
700975
Jia
Inositol trisphosphate 3-kinas ...
Mus musculus
Proc. Natl. Acad. Sci. USA
105
4739-4744
2008
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
3
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
674906
Lloyd-Burton
Regulation of inositol 1,4,5-t ...
Rattus norvegicus
J. Biol. Chem.
282
9526-9535
2007
-
-
-
-
-
-
-
-
-
3
-
-
-
7
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676129
Miller
-
Production of Ins(1,3,4,5)P4 m ...
Mus musculus
Nat. Immunol.
8
780
2007
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687650
Mayr
-
Antiproliferative plant and sy ...
Gallus gallus, Homo sapiens, Rattus norvegicus
J. Biol. Chem.
282
35424
2007
1
-
4
-
1
-
36
10
3
8
1
4
-
4
-
-
4
-
-
8
4
-
4
-
14
4
-
-
-
4
-
-
8
14
-
49
1
-
4
8
-
1
-
49
50
14
10
3
8
1
4
-
-
-
4
-
8
4
-
4
-
4
-
-
-
4
-
-
-
-
-
-
-
-
-
672478
Nalaskowski
Subcellular localisation of hu ...
Homo sapiens, Rattus norvegicus
Biol. Chem.
387
583-593
2006
-
-
2
-
-
-
-
-
4
-
-
-
-
16
-
-
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673012
Stokes
FceRI control of Ras via inosi ...
Rattus norvegicus
Cell. Signal.
18
640-651
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676178
Sun
Inhibition of rat brain inosit ...
Rattus norvegicus
Neurosci. Lett.
392
181-186
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661446
Xia
Inositol 1,4,5-trisphosphate 3 ...
Drosophila melanogaster, Homo sapiens, Rattus norvegicus, Sus scrofa
Cell Res.
15
83-91
2005
11
-
1
-
-
-
3
-
4
7
6
7
-
16
-
3
-
-
-
9
-
-
11
6
12
-
-
-
-
-
-
-
4
-
-
-
11
-
1
4
-
-
-
-
3
-
-
4
7
6
7
-
-
3
-
-
9
-
-
11
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661488
Poinas
Interaction of the catalytic d ...
Rattus norvegicus
Chembiochem
6
1449-1457
2005
-
-
1
-
-
-
8
-
-
2
-
1
-
5
-
-
1
1
-
-
-
-
2
-
1
1
-
-
-
1
-
-
1
-
-
7
-
-
1
1
-
-
-
7
8
-
-
-
2
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662346
Mayr
Antiproliferative plant and sy ...
Gallus gallus, Homo sapiens, Rattus norvegicus
J. Biol. Chem.
280
13229-13240
2005
-
-
2
-
2
-
30
10
-
6
-
3
-
14
-
-
2
-
-
1
5
-
3
-
6
3
-
-
-
3
-
-
3
1
-
-
-
-
2
3
-
2
-
-
30
1
10
-
6
-
3
-
-
-
2
-
1
5
-
3
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
663233
Resnick
Inositol polyphosphate multiki ...
Saccharomyces cerevisiae, Rattus norvegicus, Saccharomyces cerevisiae BY4741
Proc. Natl. Acad. Sci. USA
102
12783-12788
2005
-
-
1
-
-
-
-
-
2
2
1
-
-
69
-
-
2
-
-
4
-
-
3
1
7
2
-
-
-
2
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
2
2
1
-
-
-
-
2
-
4
-
-
3
1
2
-
-
-
2
-
-
-
-
-
-
-
-
-
660884
Hascakova-Bartova
Identification and subcellular ...
Mus musculus
Biochem. Biophys. Res. Commun.
323
920-925
2004
-
-
1
-
-
-
-
-
1
2
4
-
-
4
-
1
-
-
-
4
2
-
1
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
2
4
-
-
-
1
-
-
4
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660978
Brehm
Identification of the actin-bi ...
Homo sapiens, Rattus norvegicus
Biochem. J.
382
353-362
2004
-
-
2
-
1
-
-
-
2
-
-
-
-
2
-
1
1
-
-
1
-
-
4
-
4
-
-
-
-
-
-
-
2
-
-
-
-
-
2
2
-
1
-
-
-
-
-
2
-
-
-
-
-
1
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662827
Gonzalez
Structure of a human inositol ...
Homo sapiens
Mol. Cell
15
689-701
2004
1
-
1
1
8
-
1
-
-
2
-
1
-
1
-
-
1
1
-
-
-
-
2
1
2
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
1
8
-
-
1
-
-
-
2
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662828
Miller
Crystal structure of the catal ...
Rattus norvegicus
Mol. Cell
15
703-711
2004
-
-
1
1
2
-
-
-
-
1
-
-
-
3
-
-
1
1
-
-
-
-
2
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663226
Wen
Inositol (1,4,5) trisphosphate ...
Mus musculus, Mus musculus C57BL/6
Proc. Natl. Acad. Sci. USA
101
5604-5609
2004
-
-
-
-
-
-
-
-
-
-
-
4
-
144
-
-
-
-
-
1
-
-
4
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640755
Dewaste
The three isoenzymes of human ...
Homo sapiens
Biochem. J.
374
41-49
2003
-
-
1
-
1
-
-
-
6
2
-
1
-
6
-
-
-
-
-
2
1
-
3
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
3
-
1
-
-
-
-
-
6
2
-
1
-
-
-
-
-
2
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640761
Nalaskowski
Rat inositol 1,4,5-trisphospha ...
Rattus norvegicus
J. Biol. Chem.
278
19765-19776
2003
1
-
1
-
-
-
2
5
6
2
1
3
-
9
-
-
-
-
-
9
-
-
6
1
-
1
-
-
-
1
-
-
3
-
-
-
1
-
1
3
-
-
-
-
2
-
5
6
2
1
3
-
-
-
-
-
9
-
-
6
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
661334
Kwon
Synthesis of three enantiomeri ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
13
2981-2984
2003
-
-
-
-
-
-
10
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
9
-
-
-
1
-
-
-
9
10
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640752
Irvine
Back in the water: The return ...
Homo sapiens, Mammalia
Nat. Rev. Mol. Cell Biol.
2
327-338
2001
-
-
-
-
-
-
-
-
-
3
-
2
-
2
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640760
Schell
Inositol 1,4,5-trisphosphate 3 ...
Rattus norvegicus
J. Biol. Chem.
276
37537-37546
2001
1
-
1
-
-
-
-
-
4
-
-
1
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640757
Millard
Effects of elevated expression ...
Rattus norvegicus
Biochem. J.
352
709-715
2000
-
-
1
-
-
-
-
-
3
1
-
3
-
4
-
-
-
-
-
1
-
-
4
-
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
3
1
-
3
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640754
Hague
The inositol (1,4,5)-trisphosp ...
Xenopus laevis
FEBS Lett.
449
71-74
1999
-
-
-
-
-
-
4
-
2
2
-
2
-
1
-
-
-
-
-
1
1
-
3
-
-
1
-
-
-
1
-
-
3
-
-
-
-
-
-
3
-
-
-
-
6
-
-
2
2
-
2
-
-
-
-
-
1
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640758
Communi
Calcium-calmodulin-dependent p ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
274
14734-14742
1999
13
-
-
-
-
-
2
2
4
3
2
4
-
2
-
2
2
-
-
4
1
-
4
2
-
-
-
-
-
-
-
-
5
-
-
-
13
-
-
5
-
-
-
-
2
-
2
4
3
2
4
-
-
2
2
-
4
1
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640746
Collin
Serotonin induces an increase ...
Rattus norvegicus
Neurosci. Lett.
255
67-70
1998
3
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
2
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640748
Choi
-
Molecular interactions of all ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
7
2709-2714
1997
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640756
Communi
D-myo-inositol 1,4,5-trisphosp ...
Homo sapiens, Rattus norvegicus
EMBO J.
16
1943-1952
1997
6
-
1
-
-
-
4
4
-
3
2
3
-
10
-
2
1
-
-
3
2
-
5
2
-
2
-
-
-
2
-
-
5
-
-
-
6
-
1
5
-
-
-
-
8
-
4
-
3
2
3
-
-
2
1
-
3
2
-
5
2
2
-
-
-
2
-
-
-
-
-
-
-
-
-
640759
Woodring
Expression, purification, and ...
Rattus norvegicus
J. Biol. Chem.
272
30447-30454
1997
1
-
1
-
-
3
3
1
1
2
2
2
1
1
-
1
1
-
-
1
2
1
3
1
-
1
-
-
-
1
-
-
3
-
-
-
1
-
1
3
-
-
3
-
3
-
1
1
2
2
2
1
-
1
1
-
1
2
1
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640747
Carrasco
Inositol 1,4,5-trisphosphate 3 ...
Caudiverbera caudiverbera
Comp. Biochem. Physiol. B
110
747-753
1995
-
-
-
-
-
-
3
1
1
2
-
1
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
-
-
3
-
1
1
2
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
640749
Shin
-
Overexpression, purification a ...
Rattus norvegicus
Mol. Cells
5
348-353
1995
-
-
1
-
-
-
-
2
1
3
1
2
-
1
-
-
2
-
-
1
1
-
3
1
-
1
-
-
-
1
-
-
3
-
-
-
-
-
1
3
-
-
-
-
-
-
2
1
3
1
2
-
-
-
2
-
1
1
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640750
Wang
Purification and properties of ...
Bos taurus
Biochem. J.
308
1009-1016
1995
3
-
-
-
-
-
2
1
1
2
1
2
-
6
-
-
1
-
-
7
1
-
3
1
-
1
-
-
-
2
-
-
3
-
-
-
3
-
-
3
-
-
-
-
2
-
1
1
2
1
2
-
-
-
1
-
7
1
-
3
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
640751
Vanweyenberg
Tissue- and cell-specific expr ...
Homo sapiens, Rattus norvegicus
Biochem. J.
306
429-435
1995
-
-
2
-
-
-
-
-
2
2
-
-
-
8
-
-
-
-
-
11
-
-
2
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
4
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
11
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640753
Takazawa
Inositol 1,4,5-trisphosphate 3 ...
Rattus norvegicus
J. Endocrinol.
144
527-532
1995
-
-
-
-
-
-
1
-
1
2
1
2
-
1
-
-
-
-
-
1
-
-
3
1
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
2
1
2
-
-
-
-
-
1
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640733
Communi
-
Purification and biochemical p ...
Homo sapiens
Biochem. J.
298
669-673
1994
-
-
-
-
-
1
-
2
1
2
-
-
-
1
-
-
2
-
-
1
1
-
1
1
-
1
-
-
-
1
-
-
3
-
-
-
-
-
-
3
-
-
1
-
-
-
2
1
2
-
-
-
-
-
2
-
1
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640734
Lin
Purification and properties of ...
Homo sapiens
Arch. Biochem. Biophys.
303
412-420
1993
1
-
-
-
-
1
3
1
2
3
2
2
-
1
-
-
2
-
-
1
1
1
3
1
-
1
-
-
-
3
1
-
4
-
-
-
1
-
-
4
-
-
1
-
3
-
1
2
3
2
2
-
-
-
2
-
1
1
1
3
1
1
-
-
-
3
1
-
-
-
-
-
-
-
-
640736
Lee
Purification and properties of ...
Rattus norvegicus
J. Biol. Chem.
265
9434-9440
1990
-
-
-
-
-
4
1
-
-
2
1
1
1
6
-
-
1
-
-
5
2
3
2
1
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
4
-
1
-
-
-
2
1
1
1
-
-
1
-
5
2
3
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640737
Takazawa
Rat brain inositol 1,4,5-trisp ...
Rattus norvegicus
Biochem. J.
268
213-217
1990
-
-
-
-
-
-
1
1
1
4
1
-
-
9
-
-
2
-
-
1
1
-
1
1
-
1
-
-
-
1
-
-
3
-
-
-
-
-
-
3
-
-
-
-
1
-
1
1
4
1
-
-
-
-
2
-
1
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640740
Takazawa
Inhibition of inositol 1,4,5-t ...
Bos taurus
Biochem. J.
261
1059
1989
-
-
-
-
-
-
1
-
-
2
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
1
-
-
-
2
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640741
Takazawa
Purification of bovine brain i ...
Bos taurus
Biochem. J.
261
483-488
1989
-
-
-
-
-
2
1
1
2
5
4
1
-
4
-
-
1
-
-
1
1
-
2
1
-
1
-
-
-
1
-
-
4
-
-
-
-
-
-
4
-
-
2
-
1
-
1
2
5
4
1
-
-
-
1
-
1
1
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640735
Johanson
Purification of D-myo-inositol ...
Rattus norvegicus
J. Biol. Chem.
263
7465-7471
1988
-
-
-
-
-
1
1
1
-
3
4
1
-
5
-
-
2
-
-
3
2
1
2
2
-
1
-
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
1
-
1
-
1
-
3
4
1
-
-
-
2
-
3
2
1
2
2
1
-
-
-
1
1
-
-
-
-
-
-
-
-
640738
Takazawa
Ca2+/calmodulin-sensitive inos ...
Bos taurus, Rattus norvegicus
Biochem. Biophys. Res. Commun.
153
632-641
1988
-
-
-
-
-
-
4
-
2
8
-
-
-
2
-
-
2
-
-
2
-
-
2
-
-
2
-
-
-
2
-
-
4
-
-
-
-
-
-
4
-
-
-
-
4
-
-
2
8
-
-
-
-
-
2
-
2
-
-
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
640742
Yamaguchi
Purification and characterizat ...
Sus scrofa
Biochem. J.
251
129-134
1988
-
-
-
-
-
-
-
1
2
2
2
1
-
3
-
-
1
-
-
2
1
-
2
1
-
1
-
-
-
2
2
1
2
-
-
-
-
-
-
2
-
-
-
-
-
-
1
2
2
2
1
-
-
-
1
-
2
1
-
2
1
1
-
-
-
2
2
1
-
-
-
-
-
-
-
640739
Biden
Calcium-calmodulin stimulates ...
Rattus norvegicus
J. Biol. Chem.
262
9437-9440
1987
-
-
-
-
-
-
1
-
2
3
-
2
-
1
-
-
2
-
-
1
1
1
3
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
3
-
-
-
-
1
1
-
2
3
-
2
-
-
-
2
-
1
1
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640743
Yamaguchi
Calmodulin activates inositol ...
Sus scrofa
Biochem. J.
244
787-791
1987
-
-
-
-
-
-
2
-
2
4
-
1
-
6
-
-
1
-
-
2
-
-
2
-
-
1
-
-
-
1
-
-
3
-
-
-
-
-
-
3
-
-
-
-
3
-
-
2
4
-
1
-
-
-
1
-
2
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640744
Morris
Turkey erythrocytes possess a ...
Meleagris gallopavo
Biochem. J.
248
489-493
1987
-
-
-
-
-
-
-
-
3
2
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
3
2
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640745
Kimura
Activation by calmodulin of in ...
Cavia porcellus
Arch. Biochem. Biophys.
257
363-369
1987
-
-
-
-
-
-
2
-
3
3
-
-
-
6
-
-
1
-
-
4
1
-
1
-
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
3
-
-
3
3
-
-
-
-
-
1
-
4
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640731
Hansen
Formation and metabolism of in ...
Rattus norvegicus
J. Biol. Chem.
261
8100-8103
1986
-
-
-
-
-
-
-
-
2
-
-
2
-
1
-
-
1
-
-
3
2
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
2
-
-
-
1
-
3
2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640732
Irvine
The inositol tris/tetrakisphos ...
Rattus norvegicus, Xenopus sp.
Nature
320
631-634
1986
-
-
-
-
-
1
2
1
3
2
-
2
-
2
-
-
1
-
-
4
-
1
6
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
1
-
2
-
1
3
2
-
2
-
-
-
1
-
4
-
1
6
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-