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Literature summary for 2.7.1.127 extracted from

  • Xia, H.J.; Yang, G.
    Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations (2005), Cell Res., 15, 83-91.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
12-O-tetradecanoyl phorbol 13-acetate stimulating in presence of cAMP Homo sapiens
12-O-tetradecanoyl phorbol 13-acetate stimulating in presence of cAMP Rattus norvegicus
Ca2+/CaM-dependent kinase II i.e. CaMKII, activates the enzyme by phosphorylation at a Thr residue Sus scrofa
Ca2+/CaM-dependent kinase II i.e. CaMKII, activates the enzyme by phosphorylation of Thr311 Homo sapiens
Ca2+/CaM-dependent kinase II i.e. CaMKII, activates the enzyme by phosphorylation of threonine residue Rattus norvegicus
Calmodulin 2-3fold activation of isozyme IP33K-A and 7-8fold of isozyme IP33K-B, in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids Homo sapiens
Calmodulin isozyme IP33K-A: 3-6fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids, residues Ser156-Leu189 and Trp165 are required Rattus norvegicus
Calmodulin up to 20fold activation in a Ca2+-dependent manner, the binding site contains amphiphilic alpha-helices with cluster of positively charged and hydrophobic amino acids Sus scrofa
cAMP-dependent protein kinase i.e. PKA, activates the enzyme by phosphorylation at a Ser residue Sus scrofa
cAMP-dependent protein kinase i.e. PKA, activates the enzyme by phosphorylation at a serine residue Homo sapiens
cAMP-dependent protein kinase i.e. PKA, activates the enzyme by phosphorylation at Ser109, simultaneous phosphorylation at SEr109 and Ser175 inactivates the enzyme Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of enzyme D-IP3K1 leads to increased resistance of flies to H2O2, but not to paraquat-induced oxidative stress, due to a decreased 1D-myo-inositol 1,4,5-trisphosphate level Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
Protein kinase C negative regulatory function, phosphorylates the enzyme at a serine residue Homo sapiens
Protein kinase C negative regulatory function, phosphorylates the enzyme at Ser175, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme Rattus norvegicus
Protein kinase C negative regulatory function, phosphorylates the enzyme at a Ser residue Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isozyme IP33K-C Homo sapiens 5737
-
cytoskeleton isozymes IP33K-A and IP33K-B Homo sapiens 5856
-
endoplasmic reticulum isozyme IP33K-B Homo sapiens 5783
-
plasma membrane isozyme IP33K-B Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation by calmodulin in a Ca2+-dependent manner Homo sapiens
Ca2+ activation by calmodulin in a Ca2+-dependent manner Sus scrofa
Ca2+ isozyme IP33K-A: 3-6fold activation by calmodulin in a Ca2+-dependent manner Rattus norvegicus
Mg2+
-
Drosophila melanogaster
Mg2+
-
Homo sapiens
Mg2+
-
Rattus norvegicus
Mg2+
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C Homo sapiens
50900
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C Rattus norvegicus
53500
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C Homo sapiens
74000
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C Rattus norvegicus
74500
-
x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C Rattus norvegicus
75200
-
x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Drosophila melanogaster the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate Sus scrofa the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
additional information Homo sapiens the enzyme might be involved in brain development, memory, and learning ?
-
?
additional information Rattus norvegicus the enzyme might be involved in brain development, memory, and learning ?
-
?
additional information Drosophila melanogaster the enzyme might be involved in oxidative damage resistance ?
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
isozymes IP33K-A, IP33K-B, and IP33K-C
-
Rattus norvegicus
-
isozymes IP33K-A, IP33K-B, and IP33K-C
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a Ser residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating a Ser residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue Sus scrofa
phosphoprotein phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at a serine residue, cAMP-dependent protein kinase activates the enzyme by phosphorylating at a serine residue, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of Thr311 Homo sapiens
phosphoprotein phosphorylation has a regulatory function, protein kinase C inactivates the enzyme by phosphorylating the enzyme at Ser175, cAMP-dependent protein kinase activates the enzyme by phosphorylating Ser109, simultaneous phosphorylation at Ser109 and Ser175 also inactivates the enzyme, Ca2+/CaM-dependent kinase II activates the enzyme by phosphorylation of a Thr residue Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain
-
Sus scrofa
-
brain isozymes IP33K-A, IP33K-B, and IP33K-C Rattus norvegicus
-
epithelium isozyme IP33K-C Rattus norvegicus
-
heart isozymes IP33K-B, and IP33K-C Rattus norvegicus
-
lung isozyme IP33K-B Rattus norvegicus
-
testis isozymes IP33K-A, IP33K-B, and IP33K-C Rattus norvegicus
-
thymus isozyme IP33K-B Rattus norvegicus
-
tongue isozyme IP33K-C Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Drosophila melanogaster ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Sus scrofa ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview Drosophila melanogaster ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 1,4,5-trisphosphate the enzyme plays a key role in maintaining Ca2+ homeostasis by regulating the concentrations of 1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate, the enzyme has an important regulatory function in the inositol phosphate metabolism which is important for several cellular functions and signaling, overview Sus scrofa ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
additional information the enzyme might be involved in brain development, memory, and learning Homo sapiens ?
-
?
additional information the enzyme might be involved in brain development, memory, and learning Rattus norvegicus ?
-
?
additional information the enzyme might be involved in oxidative damage resistance Drosophila melanogaster ?
-
?

Subunits

Subunits Comment Organism
? x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C Homo sapiens
? x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C Rattus norvegicus
More structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain Drosophila melanogaster
More structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain Homo sapiens
More structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain Sus scrofa
More structure analysis, the isozyme A contains a F-actin binding domain, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain Rattus norvegicus

Synonyms

Synonyms Comment Organism
inositol 1,4,5-trisphosphate 3-kinase
-
Drosophila melanogaster
inositol 1,4,5-trisphosphate 3-kinase
-
Homo sapiens
inositol 1,4,5-trisphosphate 3-kinase
-
Rattus norvegicus
inositol 1,4,5-trisphosphate 3-kinase
-
Sus scrofa
IP3 3-kinase
-
Drosophila melanogaster
IP3 3-kinase
-
Homo sapiens
IP3 3-kinase
-
Rattus norvegicus
IP3 3-kinase
-
Sus scrofa
IP3K
-
Drosophila melanogaster
IP3K
-
Homo sapiens
IP3K
-
Rattus norvegicus
IP3K
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
Drosophila melanogaster
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
ATP
-
Sus scrofa