Cloned (Comment) | Organism |
---|---|
expression of isozymes IP3-3KA, IP3-3KB, and IP3-3KC in COS-7 cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
particle-bound | probably endoplasmic reticulum | Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | at 0.01 mM | Mus musculus | |
Mg2+ | - |
Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
48000 | - |
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
53000 | - |
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
98000 | - |
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
125000 | - |
x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
wild-type strain C57BL/6 and enzyme-deficient strain, 3 isozymes IP3-3KA, IP3-3KB, and IP3-3KC | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | isozyme IP3-3KB is sensitive to proteolysis at the N-terminus generating active fragments of lower molecular mass | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | higher expression of isozyme IP3-3KB | Mus musculus | - |
lung | higher expression of isozyme IP3-3KB | Mus musculus | - |
additional information | tissue-dependent expression of isozyme IP3-3KB | Mus musculus | - |
thymus | higher expression of isozyme IP3-3KB | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00044 | - |
mouse brain second particulate fraction | Mus musculus |
0.0026 | - |
recombinant enzyme in the first particulate fraction of transfected COS-7 cells | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mus musculus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
inositol 1,4,5-trisphosphate 3-kinase | - |
Mus musculus |
Ins(1,4,5)P(3) 3-kinase B | - |
Mus musculus |
IP3-3K | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |